این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Biomedical Journal، جلد ۳۰، شماره ۲، صفحات ۲۵-۲۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Adjunctive Cold Plasma Therapy in Chronic Wounds: Accelerating Healing and Reducing Infection
چکیده انگلیسی مقاله
Introduction: Chronic wounds—especially diabetic foot, venous, and pressure ulcers—pose a major global challenge. These wounds are marked by persistent infection, biofilm formation, impaired tissue regeneration, and reduced quality of life. Poor perfusion and rising antimicrobial resistance often limit the effectiveness of standard debridement and wound care strategies. Cold atmospheric plasma (CAP) has emerged as a promising adjunctive treatment due to its antibacterial and antibiofilm activity. It can also modulate wound pH and stimulate granulation tissue without harming healthy cells. Reactive oxygen and nitrogen species target multiple microbial and inflammatory pathways, enhancing wound bed preparation and healing. Strategies controlling infection and inflammation are essential for chronic wound management.
Materials and Methods: This systematic review surveyed articles from ScienceDirect, PubMed, and Scopus between 2010 and 2025 using the keywords “cold atmospheric plasma”, “chronic wounds”, “debridement”, and “biofilm”.
Results and Discussion: CAP consistently accelerated wound closure, reduced wound area, and improved healing progression. It provided faster pain relief and sustained decrease in wound pH, creating a favorable antimicrobial environment. CAP disrupted biofilms, including those formed by Methicillin‐resistant Staphylococcus aureus and Pseudomonas aeruginosa, while preserving healthy fibroblasts and keratinocytes. It also promoted proliferation, migration, angiogenesis, and granulation tissue formation. Furthermore, NRF2-mediated antioxidant pathways enhanced control of chronic inflammation. CAP demonstrated meaningful antimicrobial and regenerative benefits with minimal adverse effects.
Conclusion: CAP is a safe and promising treatment tool enhancing healing through pH modulation, microbial reduction, and tissue repair stimulation. Future research should optimize treatment parameters and standardize protocols to enable wider clinical adoption in chronic wound care.

 
""
کلیدواژه‌های انگلیسی مقاله Biofilm, Chronic wounds, Cold atmospheric plasma, Debridement, Diabetic foot ulcer
نویسندگان مقاله | Seyedeh Mahshid Razavi


| Mahdi Babadizadeh


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-887&slc_lang=other&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده other
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده کنگره
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات