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Iranian Biomedical Journal، جلد ۳۰، شماره ۱، صفحات ۱۶-۳۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Adenoviral Vectors in Gene Therapy: A Detailed Overview
چکیده انگلیسی مقاله
Adenoviral vectors (AdVs) represent one of the most extensively researched platforms in the realm of gene therapy, providing advantages such as high transduction efficiency, large transgene capacity, and broad tropism. This review provides a detailed and structured overview of AdVs, highlighting their biology, gene delivery mechanisms, clinical applications, and challenges limiting their broader therapeutic applicability. The study also explores recent progress in vector engineering, such as rare serotypes, capsid modifications, third-generation vectors, as well as strategies for immune modulation and toxicity reduction. AdVs are used in therapies for genetic disorders, oncology, and vaccinology, alongside innovations such as CRISPR-Cas9, nanotechnology, and artificial intelligence design. Nevertheless, persistent hurdles, including vector immunogenicity, hepatotoxicity, scalability, and the lack of durable expression, prevent widespread clinical use. This review consolidates current knowledge and presents a future perspective on how AdVs may evolve as powerful, adaptable, and precise tools in modern gene therapy. By contextualizing strengths and unresolved challenges, this work aims to give researchers and clinicians a balanced foundation for evaluating their future roles in translational medicine.
کلیدواژه‌های انگلیسی مقاله Adenoviridae, Genetic Therapy, Oncolytic Virotherapy, Transgene, Immunogenicity/Vaccine, CRISPR-Cas9
نویسندگان مقاله | Hamidreza Saber
Department of Cellular and Molecular Biology, Faculty of Basic Sciences, Islamic Azad University of Ardabil Branch, Ardabil, Iran


| Zahra Mousavipour
Department of Molecular Genetics and Development Biology, Faculty of Biology, University of Innsbruck, Innsbruck, Austria
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6243-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular Genetics & Genomics
نوع مقاله منتشر شده مقاله مروری
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