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Iranian Journal of Toxicology، جلد ۲۰، شماره ۱، صفحات ۱-۷
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عنوان انگلیسی Investigation of the Potential of Thymex Plus in Hematological and Platelet Modulation in Myocardial Infarction Rats
چکیده انگلیسی مقاله Background: Myocardial infarction (MI) is a common cardiovascular disease (CVD) caused by an imbalance between the high demand for blood and the heart's ability to supply it. For the first time, the present study investigated the effects of Thymex Plus (TYM), a herbal medication containing thymol extract and honey, on platelet-related indices, red cell distribution width (RDW) to platelet counts (PLT) ratio, and hemogram changes induced by isoproterenol (ISO) in a rat model .
Methods: : A total of 18 male Wistar rats were divided into three groups for the study. (I) Control, with no intervention; (II) ISO + Saline, receiving ISO (85 mg/kg, s.c.) on days 1 and 2, followed by 1.5 mL normal saline (oral) on days 3–7; and (III) ISO + TYM, receiving ISO (85 mg/kg, s.c.) on days 1 and 2, followed by 1.5 mL TYM (oral) on days 3–7. After the treatment period, blood samples were collected to evaluate hemogram parameters, including hemoglobin (Hb), hematocrit (HCT), red blood cell (RBC) and reticulocyte counts, RBC indices, PLT, and RDW-to-PLT ratio (RPR).
Results: In the ISO group, Hb, HCT, RBC, PLT, and reticulocyte counts significantly decreased (p<0.05). The ISO-TYM group showed a non-significant increase in Hb and HCT, while PLT and mean corpuscular hemoglobin concentration (MCHC) levels increased significantly (p<0.05). The RDW percentage and RPR ratio rose considerably in the ISO group (p<0.05), and TYM treatment substantially reduced these parameters (p<0.05).
Conclusion: The TYM demonstrated significant protective effects in hemogram indices, such as PLT, RDW, RDW to PLT ratio, and reticulocyte count on ISO-induced MI in rats. These effects included improvements. The results of the present study enhanced the potential of TYM as a compound with hematological modulating capabilities. However, to clarify the precise mechanisms of these effects, further studies are recommended.
 
کلیدواژه‌های انگلیسی مقاله Blood Platelets, Honey, Isoproterenol (ISO), Rats, Red Cell Distribution Width, Thymol, Wistar
نویسندگان مقاله | Sina Adib
DVM, Veterinary Medicine, Semnan University, Semnan, Iran.


| Keivan Keramati
Department of Basic Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.


| Mahmood Ahmadi-hamedani
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.


| Leila Mohammadnezhad Nasrabadi
Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-605-2&slc_lang=en&sid=1
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