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Iranian Journal of Toxicology، جلد ۲۰، شماره ۱، صفحات ۱۶-۲۸
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عنوان انگلیسی Orlistat Administration: Cardiopulmonary Oxidative Stress and Histological Responses in Obese Rats
چکیده انگلیسی مقاله Background: Orlistat, while reducing dietary fat absorption for obesity, presents risks: pancreatic, hepatic, renal, and cerebellar damage.
Methods: This study investigated Orlistat heart and lung toxicity, lacking in prior research. Male rats were split for five set (five each group): group 1, (C/A) was normal diet ; group 2, (C/B): Was given 30% the high fat diet; group 3, (OS-360 mg/kg); group 4, (OS-480 mg/kg); group 5, (OS-600 mg/kg). Rats were administered orally daily for 60 days.
Results: The obtained results from heart tissues that orlistat induces dose-dependent oxidative stress, evidenced by increased Reactive Oxygen Species (ROS) and altered peroxiredoxin, may have deleterious effects on heart tissue and may not protect against high-fat diet-induced damage. Also in lung tissues high-dose Glutathione S-Transferase (GST) increase, biphasic ROS response, and peroxiredoxin changes with fat/low-dose Orlistat. Orlistat may have adverse effects on lung tissue, and may not protect against damage caused by a high-fat diet.
Conclusion: The orlistat have adverse heart and lung effects and dose-dependent oxidative stress.
 
کلیدواژه‌های انگلیسی مقاله Orlistat, Anti-obesity drug, High-fat diet, Cardiopulmonary, Histology
نویسندگان مقاله | Emam Atiyah Ibadi IBADI
Department of Environment, College of Science, University of Al-Qadisiyah, Diwaniyah, Iraq.


| Hussein Kamil Awad Awad
Unit of Environment and Prevention of Pollution, College of Science, University of Al-Qadisiyah, Diwaniyah, Iraq.


| Zainab Hudhi Farhoord Farhoord
Department of biology, Faculty of Education for Pure Science, University of Thi-Qar, Thi-Qar, Iraq.


| Bilal Husam Jasim Jasim
Biotechnology Department, Collage of Applied Sciences, University of Technology – Iraq.


| Sabrean Farhan Jawad Jawad
College of pharmacy Al- Mustaqbal University, 51001 Babil, Iraq.
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1413-1&slc_lang=en&sid=1
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