این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
گوارش، جلد ۳۰، شماره ۳، صفحات ۱۵۴-۱۵۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی IL-33 Levels in the Esophageal Biopsy Specimen on Patients with Erosive and Non-Erosive Reflux Esophagitis
چکیده انگلیسی مقاله Background: IL-33, a tissue-derived cytokine, plays an important role in inflammatory responses. This study aimed to evaluate the interleukin-33 (IL-33) marker in esophageal biopsy samples from patients with erosive reflux disease (ERD) and non-erosive reflux disease (NERD) in comparison with a control group. Materials and Methods:   In this study, tissue samples were obtained from 54 patients (27 with ERD and 27 with NERD) and 27 controls. Tissue contents of IL-33 were measured using Enzyme-Linked Immunosorbent Assay (ELISA). Additionally, the Bradford method was employed to determine the protein concentration of the samples. Our results were analyzed by SPSS software (Version 22.0). The P<0.05 was considered a significant level. Results: The mean concentration (mean ±SD) of IL-33 in the NERD, ERD, and control groups was 439.06± 135.47, 511.83±137.75, and 206.09± 76.03 pg/mgp, respectively. A significant difference was observed between patients with NERD, ERD, and healthy subjects in terms of IL-33 levels (P=0.072). Conclusion: This study provides new evidence to support a major role of IL-33 in distinguishing patients with ERD and NERD subtypes. IL-33 level may serve as a biomarker for the progression and development of gastroesophageal reflux disease (GERD). These data may support the recommendation of IL-33 measurement in patients with GERD for making informed decisions about further drug treatment strategies and for monitoring this type of disease.
کلیدواژه‌های انگلیسی مقاله Esophageal biopsy,Erosive esophagitis,Gastroesophageal reflux disease,IL-33,Non-erosive reflux disease
نویسندگان مقاله | Fatemeh Mahmoudlou
Babol University of Medical Sciences


| Durdi Qujeq


| Fatemeh Nejat Pish Kenari


| Seyed Saeid Mohammady Bonahi
Department of Internal Medicine, Gastroenterology Division, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, IRAN


| Mehrdad Kashifard Mehrdad Kashifard
Department of Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, IRAN


| Karimollah Hajian -Tilaki


نشانی اینترنتی https://govaresh.org/index.php/dd/article/view/2757
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات