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Iranian Journal of Medical Physics، جلد ۲۲، شماره ۵، صفحات ۳۲۱-۳۳۰
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عنوان انگلیسی Efficiency of Low Alpha Dose Therapy for Achieving Complete Skin Tissue Regeneration
چکیده انگلیسی مقاله Introduction: The process of wound healing represents a dynamic and multifaceted phenomenon characterized by intricate cellular and molecular mechanisms aimed at the restoration of tissue integrity. The present study examined the impact of low-dose ionizing radiation, particularly alpha particles released by americium-241, on the process of wound healing in murine experimental models. Material and Methods: Twenty-four male mice were randomly divided into three groups: a control group (CG) and two experimental groups exposed to radiation for 5 minutes (IG-5) and 15 minutes (IG-15), respectively (n = 8 per group). Each mouse received two 8 mm circular full-thickness skin excisions on the dorsum. Wound healing was evaluated over 10 days using photographic analysis (quantified via ImageJ software) and histological assessment. Results: Results indicated significantly enhanced wound closure in both irradiated groups, particularly IG-15, compared to the CG. Biochemical analyses revealed elevated levels of growth factors in irradiated tissues. Histological findings showed increased collagen deposition, greater fibroblast proliferation, and reduced inflammatory cell infiltration in the experimental groups. Conclusion: These findings suggest that controlled low-dose alpha radiation, particularly in the IG-15 protocol, may beneficially modulate the wound healing process and hold potential for novel therapeutic applications.
کلیدواژه‌های انگلیسی مقاله Radiobiology, Wound healing, Alpha Particles, Proliferation, Mice
نویسندگان مقاله | Madyan Khalaf
Department of Physics, College of Sciences, Mustansiriyah University, Baghdad, Iraq


| Baida Ahmed
Department of Physics, College of Sciences, Mustansiriyah University, Baghdad, Iraq


| Sahar Al-Sharqi
Department of Biology, College of Sciences, Mustansiriyah University, Baghdad, Iraq
نشانی اینترنتی https://ijmp.mums.ac.ir/article_27220.html
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نوع مقاله منتشر شده Original Paper
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