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Iranian Journal of Medical Physics، جلد ۲۲، شماره ۴، صفحات ۲۱۸-۲۲۹
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عنوان انگلیسی Radiomics-Based Machine Learning to Support Visual Assessment for Improved Epilepsy Classification Using 18F-FDG Brain PET
چکیده انگلیسی مقاله Introduction: This study explored radiomics-based machine learning (ML) models as complementary tools to visual evaluation for classifying drug-resistant epilepsy patients and healthy controls using 18F-FDG brain Positron Emission Tomography (PET). Because visual interpretation can be subjective and variable, especially for novice readers, objective and reproducible computational methods are needed.Material and Methods: Twenty-one drug-resistant epilepsy patients and sixteen healthy controls underwent ¹⁸F-FDG brain PET imaging. From contralateral brain regions, 92 radiomics features (first-order statistics and second-order texture matrices) were extracted. Feature selection included Student’s t-test, principal component analysis, and ridge regression. Logistic regression (LR) and support vector machine (SVM) classifiers were trained and evaluated using 10-fold cross-validation and repeated 80/20 train–test splits. A permutation test (n = 1000) assessed whether differences between classifier performances were statistically significant. LR, chosen for its lower computational cost and interpretability, was used for comparison with human visual assessments.Results: Across six radiomics feature groups, LR models demonstrated strong performance, with mean accuracy of 0.94(0.05), precision 0.96(0.03), recall 0.92(0.10), specificity 0.97(0.02), and AUC 0.98(0.00). SVM models showed similarly high accuracy 0.98(0.01), precision 0.94(0.05), recall 0.96(0.03), specificity 0.98(0.01), and AUC 0.98(0.00). Novice visual assessments had moderate accuracy (0.62 and 0.67), perfect specificity, lower sensitivity (0.60 and 0.65), and AUCs of 0.80 and 0.825. The final LR model achieved a mean AUC of 0.96(0.01).Conclusion: This hybrid radiomics-visual approach improves classification accuracy in pre-surgical evaluation of drug-resistant epilepsy. By integrating quantitative radiomics with clinical interpretation, the framework reduces variability and improves reliability for less experienced clinicians.
کلیدواژه‌های انگلیسی مقاله Radiomics, Brain PET Imaging, Epilepsy, classification, Machine Learning
نویسندگان مقاله | Naghmeh Firouzi
Research Center for Molecular and Cellular Imaging, Advanced Medical Technologies and Equipment Institute, Tehran University of Medical Sciences, Tehran, Iran


| Hossein Ghadiri
Medical Physics and Biomedical Engineering Dept., Medical School, Tehran University of Medical Sciences


| Elnaz Jenabi
Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Parham Geramifar
Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijmp.mums.ac.ir/article_27059.html
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