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Iranian Journal of Medical Physics، جلد ۲۲، شماره ۴، صفحات ۲۴۱-۲۴۶
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عنوان انگلیسی Radioprotective Effect of Ferula Asafoetida Oleo-Gum Resin on Ionizing Radiation–Induced Oxidative Stress and Tissue Damage in Rats
چکیده انگلیسی مقاله Introduction: Protective agents against harmful radiation have been studied for decades. Antioxidants can protect normal tissues by scavenging free radicals generated during irradiation. Ferula asafoetida (AS), a medicinal plant with antioxidant activity, was evaluated in this study for its protective effect against radiation-induced small intestinal injury in rats.Material and Methods: Thirty-five Wistar rats were randomly divided into five groups (n=7): control, irradiated (R), irradiated+AS (R+AS), irradiated+vitamin E (R+E), and irradiated+AS+E (R+AS+E). Treatments included AS (100 mg/kg) and/or vitamin E (20 mg/kg) daily for eight days. On day six, irradiated groups received 6 Gy X-rays (6 MV, Elekta, Stockholm, Sweden). On day eight, rats were euthanized and intestine and liver tissues collected. Histopathology, malondialdehyde (MDA), and glutathione (GSH) levels were analyzed.Results: AS significantly reduced MDA and increased GSH levels in both intestine and liver. Vitamin E showed weaker effects. The combination of AS and vitamin E did not consistently enhance AS activity. Histological analysis revealed that AS reduced inflammation and atrophy, while vitamin E alone or combined with AS lowered inflammation and epithelial erosion. Neither treatment increased mucous cell counts.Conclusion: AS exerted notable antioxidant and radioprotective effects against intestinal damage in rats, indicating its potential as a natural agent for mitigating radiation-induced injury.
کلیدواژه‌های انگلیسی مقاله Ferula Asafoetida, Radiation Protection, Small intestine, Vitamin E, Oxidative stress
نویسندگان مقاله | soheila safardoost
Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


| Shokouhozamanozaman Soleymanifard
Associate Professor of Medical Physics, Research Center of Medical Physics, Mashhad University of Medical Sciences, Mashhad, Iran


| vahidreza askari
Neurogenic Inflammation Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran


| Morteza Rezaei kahkha
Department of Medical Physics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.


| Shirin Taraz Jamshidi
Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.


| mahdi karimi
Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran


| Hamid Gholamhosseinian
Medical Physics Dept, Faculty of Medicine, Mashhad University of Medical Sciences
نشانی اینترنتی https://ijmp.mums.ac.ir/article_27061.html
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نوع مقاله منتشر شده Original Paper
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