این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Medical Physics، جلد ۲۲، شماره ۴، صفحات ۲۷۹-۲۸۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Comparing the Influence of Different-Order HIFU Harmonic Superposition on Focal Temperature of Biological Tissue
چکیده انگلیسی مقاله Introduction: While high-intensity focused ultrasound (HIFU) is widely used for non-invasive tumor ablation, current models fail to account for the cumulative energy contributions of nonlinear harmonics (up to the 256th order), significantly limiting treatment precision. This study quantifies the role of harmonic superposition (1st+2nd+…+256th order) in regulating HIFU-induced focal temperature and establishes an optimized harmonic combination to enhance clinical parameter design.   Material and Methods: A coupled acousto-thermal model, validated against MRI thermometry, was developed by solving the Westervelt equation and Pennes bioheat equation to simulate nonlinear acoustic propagation and transient temperature fields in ex vivo porcine muscle under HIFU irradiation. Results: The 1st+2nd+...+128th harmonic superposition model achieved <2.2% error in focal temperature prediction across all tested power levels (80–200 W), with errors of 1.6% at 80 W (48.18 °C simulated vs. 47.96 °C measured), 1.1% at 140 W (66.0 °C vs. 65.31 °C), 1.8% at 160 W (77.78 °C vs. 76.38 °C), and 2.2% at 200 W (82.25 °C vs. 84.11 °C). Mid-order harmonics (2nd–64th) contributed 75–80% of energy deposition, while high-order harmonics (>128th, e.g., 256th at 276.48 MHz) exhibited severe attenuation (135× higher than the fundamental wave). The linear propagation model (fundamental frequency only) underestimated temperatures by 4.8-23.9%, highlighting the necessity of nonlinear harmonic inclusion. Conclusion: This work establishes a harmonically optimized framework for HIFU treatment planning, addressing a critical gap in nonlinear acoustic modeling and enabling safer, precision thermal therapy.
کلیدواژه‌های انگلیسی مقاله High, Intensity Focused Ultrasound Harmonic Temperature Thermal Therapy Nonlinear
نویسندگان مقاله | HU DONG
School of Information Science and Engineering, Changsha Normal University, Changsha 410100, China


| GANG LIU
School of Information Science and Engineering, Xinyu University, Xinyu, 338004, China


| Xilong Qu
School of Information Science and Engineering, Changsha Normal University, Changsha 410100, China
نشانی اینترنتی https://ijmp.mums.ac.ir/article_27081.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Paper
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات