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عنوان انگلیسی Allium jesdianum Attenuates Oxidative Stress and Inflammatory Responses in the Liver of Cyclophosphamide-Treated Mice
چکیده انگلیسی مقاله Introduction
The liver is essential for drug metabolism and detoxification, and cyclophosphamide (CTX) can trigger hepatotoxicity via oxidative stress and inflammatory responses. Allium jesdianum has antioxidant and anti-inflammatory effects that may mitigate CTX-induced liver injury. This study investigates whether the antioxidant properties of A. jesdianum can protect organ function in a CTX-treated animal model, with implications for potential adjunctive strategies in CTX therapy.
Methods and materials
Twenty male NMRI mice divided randomly into 4 groups (n=5 per group): normal saline for 14 days (oral), A. jesdianum extract at 200 mg/kg daily for 14 days (oral), CTX at 20 mg/kg intraperitoneal (IP) for 5 days, and A. jesdianum extract at 200 mg/kg (oral) daily for 14 days + CTX at 20 mg/kg IP during the last 5 days. Tissue samples were collected and analyzed for lipid peroxidation, antioxidant enzyme activity, and inflammatory cytokines.
Results:
CTX increased thiobarbituric acid reactive substances (TBARS), which were attenuated by A. jesdianum (P < 0.001). Antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were adversely modulated by CTX and markedly ameliorated by A. jesdianum pretreatment (p < 0.001). Pro-inflammatory cytokines (interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-alpha (TNF-α) were increased in the CTX group, which was significantly decreased by A. jesdianum (p < 0.001, p < 0.001, and p < 0.01, respectively).
Conclusion
A. jesdianum suggests attenuating CTX-associated liver toxicity by dampening oxidative stress and inflammatory responses, thereby supporting its prospective role as a natural cytoprotective adjunct in chemotherapy regimens.
کلیدواژه‌های انگلیسی مقاله Allium jesdianum,Liver,Pro-inflammatory cytokines,Antioxidant enzymes
نویسندگان مقاله KOBRA SHIRANI |
Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Alireza Rezaei |
1. Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Bahareh Sadat Yousefsani |
3. Department of Traditional Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran.

Ameneh Omidi |
Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

نشانی اینترنتی https://mjms.modares.ac.ir/article_27987_e3bff3cd294df3b24f6fe9e700d86a91.pdf
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