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Iranian Journal of Parasitology، جلد ۱۱، شماره ۳، صفحات ۳۰۳-۳۱۵
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عنوان انگلیسی Increased CD11b and Hypoxia-Inducible Factors-1alpha Expressions in the Lung Tissue and Surfactant Protein-D Levels in Serum Are Related with Acute Lung Injury in Severe Malaria of C57BL/6 Mice
چکیده انگلیسی مقاله Background: We aimed to reveal the role of CD11b and hypoxia-inducible factors-1alpha (HIF-1α) expressions on monocytes and alveolar macrophages of lung tissue, and the levels of serum surfactant protein-D (SP-D) in severe malaria-associated acute lung injury (ALI). Methods: The C57BL/6 mice were divided into control group, renal malaria group (inoculated with 10 6 Plasmodium berghei ANKA), and cerebral malaria group (inoculated with 10 7 P. berghei ANKA). The expressions of CD11b and HIF-1α in lung tissue were observed by immunohistochemistry, and serum SP-D levels were measured by ELISA. This study was conducted from June 2014 to February 2015 in the Laboratory of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang. Results: The CD11b expression on pulmonary tissue of renal and cerebral malaria mice were significantly higher than control mice ( P =0.002; P =0.002), as well as the HIF-1α expression on pulmonary tissue ( P =0.002; P =0.002). The level of serum SP-D in renal malaria and cerebral malaria mice were significantly higher than control mice ( P =0.002; P =0.002). We found a strong correlation between the expression of CD11b and HIF-1α in lung tissue (r=0.937, P =0.000), as well as between CD11b expression and serum SP-D levels (r=0.907, P =0.000) and between HIF-1α expression and serum SP-D levels (r=0.913, P =0.000). Conclusion: Severe malaria-associated ALI increased the expression of CD11b and HIF-1α in the lung tissue and increased serum SP-D levels of C57BL/6 mice significantly.
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نویسندگان مقاله wike astrid cahayani | wike astrid cahayani


eviana norahmawati | eviana norahmawati


niniek budiarti | niniek budiarti


loeki enggar fitri | loeki enggar fitri


نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1199
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