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Iranian Journal of Parasitology، جلد ۱۱، شماره ۱، صفحات ۴۶-۵۱
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عنوان انگلیسی In Vitro Susceptibility of Iranian Isolates of Trichomonas vaginalis to Metronidazole
چکیده انگلیسی مقاله Background: Metronidazole, a 5-nitroimidazole derivative, is the main antitrich­omonal agent of choice for treatment of t richomoniasis . Since 1962, s ome cases of treatment failure with metronidazole have been reported and recently drug re­sistance is now on the rise in the world. This study was aimed to determine current susceptibility of Iranian isolates of Trichomonas vaginalis to metronidazole. Methods: This study was performed on 50 T. vaginalis isolates collected from west and central areas of Iran. After axenisation of the parasites, susceptibility testing was carried out by using serial twofold dilutions of metronidazole (400 to 0.1 µg/ml). The minimum inhibitory concentration (MIC) and the minimum lethal concentration (MLC) of the trichomonads were determined after 48 h incubation at 35.5 °C. Drug susceptibility assays of the all isolates were carried out two times in triplicate under aerobic and anaerobic conditions. Results: Ninety-eight percent of the T. vaginalis isolates (49/50) were sensitive to metronidazole. Metronidazole resistance was defined as aerobic MIC ≥50 µg/ml, detected in one isolate. The means of aerobic MICs and MLCs and that of anaero­bic MICs of the parasites were 2.91, 1.95 and 0.28 µg/ml, respectively. Conclusion: This investigation showed in vitro low-level tolerance to metronida­zole in a few T. vaginalis isolates that may be leading to the development of drug resistance.
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نویسندگان مقاله محمد متینی | mohammad matini


امیر حسین مقصود | amir hossein maghsood


مهدی محبعلی | mahdi mohebali


صغری ربیعی | soghra rabiee


محمد فلاح | mohammad fallah


ساسان رضایی | sassan rezaie


مصطفی رضاییان | mostafa rezaeian


نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/809
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