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Iranian Journal of Parasitology، جلد ۱۰، شماره ۴، صفحات ۵۶۱-۵۷۰
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عنوان انگلیسی Encephalitozoon cuniculi infection among immunocompro-mised and immunocompetent humans in Egypt
چکیده انگلیسی مقاله Background: Encephalitozoon cuniculi infects a wide range of homoeothermic animals, including man. Complications due to this microsporidian have been reported only in immunocompromised patients. Reports on E. cuniculi in immunocompetent humans are lacking, most probably, because it is not linked to any clinical manifestations in such hosts. The present work was carried out with the aim of studying, for the first time in Egypt, the prevalence of E. cuniculi infection of urinary tract among non-HIV immunocompromised patients and immunocompetent individuals. It tested also the influence of some factors on the risk of infection. Methods: Blood and urine samples were collected from 88 persons (44 non-HIV immunocompromised patients and 44 subjects as immunocompetent control group). IFAT serological assay and Weber’s green modified trichrome stain (MTS) urine smears were carried out. Molecular study by PCR was also performed to detect DNA of E. cuniculi in urine samples. A full history sheet was fulfilled for each subject to test the suspected risk factors. Results: The IFAT examination confirmed the presence of antibodies against E. cunic­uli in 44.3% of the human subjects. The seroprevalence of E. cuniculi was significantly higher in the immunocompromised patients compared with the immunocompetent individuals (77.3% versus 11.4%). Compared with IFAT (the gold standard), the sensitivity and specificity of Weber’s green MTS smears were 69.23% and 89.80%. By using PCR, no positive cases were detected among human subjects. Conclusion: A high prevalence of E. cuniculi infection in the studied individuals was noted. Although infection was found in some immunocompetent individuals, the im­mune status of the host remains the corner stone for occurrence of the infection.
کلیدواژه‌های انگلیسی مقاله Protozoa,Man,Microsporidia,Opportunistic
نویسندگان مقاله somaia سیف ابو akkada | somaia saif abu akkada
parasitology department, faculty of veterinary medicine, alexandria university, egypt


ایمان دری حسین el kerdany | eman dorry hussein el kerdany
medical parasitology department, faculty of medicine, alexandria university, egypt


راشا fadly mady | rasha fadly mady
medical parasitology department, faculty of medicine, alexandria university, egypt


radwa جلال diab | radwa galal diab
medical parasitology department, faculty of medicine, alexandria university, egypt


gehan عبد elatti khedr | gehan abd elatti khedr
clinical oncology department, faculty of medicine, alexandria university, egypt


کرم امام ashmawy | karam imam ashmawy
parasitology department, faculty of veterinary medicine, alexandria university, egypt


wael محمد لطفی | wael mohamed lotfy
parasitology department, medical research institute, alexandria university, egypt
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/655
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زبان مقاله منتشر شده en
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