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Iranian Journal of Parasitology، جلد ۱۰، شماره ۴، صفحات ۶۲۵-۶۳۱
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عنوان انگلیسی Efficacy of the Bunium persicum (Boiss) Essential Oil against Acute Toxoplasmosis in Mice Model
چکیده انگلیسی مقاله Background: We evaluated the in vivo activity of Bunium persicum (Boiss) essential oil on infected mice with acute toxoplasmosis. Methods: To evaluate prophylactic effects, male NMRI mice received B. persicum essential oil at the concentrations of 0.05 and 0.1 mL/kg for 14 days . After 24 h mice were infected intraperitonealy with 1×10 4 tachyzoites of T. gondii, RH strain. In order to investigate therapeutic effects, mice were infected and then received B. persicum oil at the concentrations of 0.05 and 0.1 ml/kg two times a day for 5 days. The time/mean time of death in all infected mice and the number of tachyzoites from infected mice were recorded. Results: The time/mean time of death of infected mice was 8 and 9 days after oral administration of B. persicum oil at the concentration of 0.05 and 0.1 mL/kg, respectively ( P < 0.05). In contrast, the time/mean time of death control group was 5 days. In addition, B. persicum significantly reduced the mean number of tachyzo­ites compared with control group. The time/mean time of death of infected mice was 6 and 7 days after oral administration of B. persicum essential oil at the concentra­tion of 0.05 and 0.1 mL/kg, respectively. In contrast, the time/mean time of death control group was 5 days. B. persicum especially at the concentration of 0.1 ml/kg significantly reduced the mean number of tachyzoites compared with con­trol group. Conclusion: The results showed the potential of B. persicum essential oil as a natu­ral source for the production of new prophylactic agent for use in toxoplasmosis.
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نویسندگان مقاله امیر توکلی kareshk | amir tavakoli kareshk
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

امیر کیهانی | amir keyhani
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

حسین محمودوند | hossein mahmoudvand
research center for tropical and infectious diseases, kerman university of medical science, kerman, iran


راضیه توکلی اولیایی | razieh tavakoli oliaei
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

آرش اسدی | arash asadi
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

معظمه اندیشمند | moazameh andishmand
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

حسین azzizian | hossein azzizian
department of physiology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

زهرا بابایی | zahra babaei
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

ناصر ضیای علی | naser zia ali
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/664
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