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Iranian Journal of Parasitology، جلد ۱۰، شماره ۳، صفحات ۳۸۹-۴۰۱

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عنوان انگلیسی Interleukin-18 Antagonism Improved Histopathological Condi¬tions of Malaria Infection in Mice
چکیده انگلیسی مقاله Background: Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathologi­cal conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice. Methods: Plasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treat­ment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney. Results: Treatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice. Conclusion: IL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.
کلیدواژه‌های انگلیسی مقاله Malaria,Interleukin-18,Plasmodium berghei,Histopathology

نویسندگان مقاله مرضیه jabbarzare | marzieh jabbarzare
dept. of human anatomy, faculty of medicine amp;amp; health sciences, universiti putra malaysia, selangor, malaysia


voon kin چین | voon kin chin
dept. of biomedical sciences, faculty of medicine amp;amp; health sciences, universiti putra malaysia, selangor, malaysia


herni talib | herni talib
dept. of pathology, faculty of medicine amp;amp; health sciences, universiti putra malaysia, selangor, malaysia


mun fei یام | mun fei yam
school of pharmaceutical sciences, universiti sains malaysia, penang, malaysia


siti خدیجه آدم | siti khadijah adam
dept. of human anatomy, faculty of medicine amp;amp; health sciences, universiti putra malaysia, selangor, malaysia


هانیزا حسن | haniza hassan
dept. of human anatomy, faculty of medicine amp;amp; health sciences, universiti putra malaysia, selangor, malaysia


roslaini بینتی مجید | roslaini abdul majid
dept. of medical microbiology and parasitology, faculty of medicine amp;amp; health sciences, universiti putra malaysia,selangor, malaysia


che norma mat تایب | che norma mat taib
dept. of human anatomy, faculty of medicine amp;amp; health sciences, universiti putra malaysia, selangor, malaysia


محمد آریس محمد moklas | mohamad aris mohd moklas
dept. of human anatomy, faculty of medicine amp;amp; health sciences, universiti putra malaysia, selangor, malaysia


محمد taufik هدایت | mohamad taufik hidayat
dept. of human anatomy, faculty of medicine amp;amp; health sciences, universiti putra malaysia, selangor, malaysia


hasidah محمد sidek | hasidah mohd sidek
school of biosciences and biotechnology, faculty of science and technology, universiti kebangsaan malaysia, malaysia


rusliza بصیر | rusliza basir
dept. of human anatomy, faculty of medicine amp;amp; health sciences, universiti putra malaysia, selangor, malaysia



نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/304
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