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Iranian Journal of Parasitology، جلد ۱۰، شماره ۳، صفحات ۴۰۲-۴۰۹
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عنوان انگلیسی Influence of Toxoplasma gondii Infection on Male Fertility: A Pilot Study on Immunocompetent Human Volunteers
چکیده انگلیسی مقاله Background: This study was conducted to investigate the influence of Toxoplasma gondii infection on spermatic and hormonal parameters in a pilot sample of immunocompe­tent human male subjects. Methods: This cross sectional, observational pilot study on 60 immunocompetent hu­man male subjects aged between 18 and 60 yr old was conducted between 2012 -2013. Blind evaluation of serological markers of past T. gondii infection (TOX-IgG, TOX-IgM) was performed, along with individual spermiograms and determinations of folli­cle-stimulating hormone (FSH) and testosterone serum levels. Results: The overall prevalence of past T. gondii infection in the investigated immunocom­petent male subjects was 25%. No statistically significant influence of T. gondii infection on sperm characteristics (ejaculate quantity, sperm count, motility, morphol­ogy) and serum levels of FSH or testosterone were found. Among possible predictors of a modified spermiogram studied by multiple logistic regression along with the T. gondii infection (age, smoking, alcohol consumption, fertility influencing malfor­mations, infections, trauma or medication), only the presence of varicocele in the medi­cal history of the studied subjects was found to significantly participate in the predic­tion of a modified spermiogram (P=0.0154). A necessary sample size of 994 subjects was computed in order to achieve a test power of 0.8 (80%) to discriminate an effect size of 8.89% estimated by our pilot study. Conclusions: Although our investigation did not demonstrate an influence of latent T. gondii infection on spermatic and hormonal parameters of immunocompetent male hu­mans, the absence of such an influence cannot be affirmed, due to the limited sample size of our pilot study. 
کلیدواژه‌های انگلیسی مقاله latent toxoplasmosis,TOX-IgG,spermiogram,FSH,testosterone
نویسندگان مقاله horaţiu آلکساندرا colosi | horaţiu alexandru colosi
dept. of medical informatics and biostatistics, “iuliu haţieganu” university of medicine and pharmacy, cluj-napoca, romania


بابک جلالی زاده | babak jalali zadeh
dept. of urology, municipal hospital, dej, romania


ioana آلینا colosi | ioana alina colosi
dept. of microbiology, “iuliu haţieganu” university of medicine and pharmacy, cluj-napoca, romania


لورا mihaela سیمون | laura mihaela simon
dept. of microbiology, “iuliu haţieganu” university of medicine and pharmacy, cluj-napoca, romania


carmen anca costache | carmen anca costache
dept. of microbiology, “iuliu haţieganu” university of medicine and pharmacy, cluj-napoca, romania
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/539
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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