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Iranian Journal of Parasitology، جلد ۹، شماره ۱، صفحات ۲۸-۳۶
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عنوان انگلیسی In Vitro Inhibitory Effect of Berberis vulgaris (Berberidaceae) and Its Main Component, Berberine against Different Leishmania Species.
چکیده انگلیسی مقاله Background: Leishmaniasis has been identified as a major public health problem in tropical and sub-tropical countries. The present study was aimed to investigate antileishmanial effects of various extracts of Berberis vulgaris also its active com-poenent, berberine against Leishmania tropica and L. infantum species on in vitro ex-periments. Methods : In this study in vitro antileishmanial activity of various extracts of B. vul-garis also its active compoenent, berberine against promastigote and amastigote stages of L. tropica and L. infantum was evaluated, using MTT assay and in a macro-phage model, respectively. Furthermore, infectivity rate and cytotoxicity effects of B. vulgaris and berberine in murine macrophage cells were investigated. Results : The findings of optical density (OD) and IC 50 indicated that B. vulgaris particulary berberine significantly ( P < 0.05) inhibited the growth rate of pro-mastigote stage of L.tropica and L.infantum in comparison to meglumine antimoniate (MA). In addition, B. vulgaris and berberine significantly ( P < 0.05) decreased the mean number of amastigotes in each macrophage as compared with positive con-trol. In the evaluation of cytotoxicity effects, it could be observed that berberine as compared with B. vulgaris exhibited more cytotoxicity against murine macrophages. Results also showed that when parasites were pre-incubated with B. vulgaris their ability to infect murine macrophages was significantly decreased. Conclusion : B.vulgaris particularly berberine exhibited potent in vitro leishmanicid-al effects against L. tropica and L.infantum . Further works are required to evaluate the antileishmanial effects of B.vulgaris on Leishmania species using clinical settings.
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نویسندگان مقاله حسین محمودوند | hossein mahmoudvand
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran and leishmaniasis research center, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

فریبا شریفی فر | fariba sharififar
dept. of pharmacognosy, faculty of pharmacy, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

ایرج شریفی | iraj sharifi
leishmaniasis research center, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

بهروز عزت پور | behrouz ezatpour
razi herbal medicines research center, lorestan university of medical sciences, khorramabad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی لرستان (Lorestan university of medical sciences)

مجید فصیحی هرندی | majid fasihi harandi
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

مهسا سادات مکی | mahsa sadat makki
dept. of medical parasitology, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ناصر ضیای علی | naser zia ali
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

ساره جهانبخش | sareh jahanbakhsh
dept. of medical parasitology and mycology, kerman university of medical sciences, kerman, iran and leishmaniasis research center, kerman university of medical sciences, kerman, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/436
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