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Iranian Journal of Parasitology، جلد ۸، شماره ۴، صفحات ۵۱۰-۵۱۵
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عنوان انگلیسی Differential genomics output and susceptibility of Iranian patients with unilocular hydatidose.
چکیده انگلیسی مقاله Background: The objective of this study was to investigate HLA-DRB1*and DQB1* allelic polymorphisms in Iranian patients with hydatidose. This is the first survey dealing with the correlation between HLA-DRB1* and DQB1* al-leles and cystic echinococcosis in Iranian patients. Methods : The study was carried out on 56 patients with confirmed cystic echi-nococcosis and 30 apparently healthy individuals living in Arak- Markazi Prov-ince by HLA-DRB1 and DQB1 typing through PCR-SSP method. The first step was to identify the patients and blood sampling. DNA was prepared from whole blood and PCR-SSP with 31 primer mixes for per sample was used. PCR reaction mixtures were loaded in agarose gels and bands were observed under UV illumination and gel document after electrophoresis. Analysis of results was carried out with specific softwares and frequency and interpretation tables for calculation of P -value in χ2 test were provided via Fisher΄s exact test. Signifi-cant samples were analyzed by logistic regression and odds-ratios were calculat-ed. Results : A statistically significant positive association was found between HLA-DQB1*03 and the resistance to cystic echinococcosis ( P < 0.02) (odds-ratio=2.87). Conclusion : Immunogenetic susceptibility to unilocular hydatidose varies ac-cording to the HLA antigens in Arak, Markazi Province, and DQB1*03 mole-cules are associated with the level of immune response to parasite antigens.
کلیدواژه‌های انگلیسی مقاله DQB1,Echinococcosis,HLA-DRB1,Hydatidose,PCR-SSP
نویسندگان مقاله مهدی مسیبی | mahdi mosayebi
dept. of parasitology, medical faculty, arak university of medical sciences, arak, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

عبدالحسین دلیمی اصل | abdolhossein dalimi asl
dept. of parasitology, medical sciences faculty, university of tarbiat modarres, tehran, iran.


محمد موذنی | mohammad moazzeni
dept. of immunology, medical sciences faculty, university of tarbiat modarres, tehran, iran.


قاسم مسیبی | ghasem mosayebi
dept. of immunology, medical faculty, arak university of medical sciences, arak, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اراک (Arak university of medical sciences)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/461
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