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Iranian Journal of Parasitology، جلد ۸، شماره ۱، صفحات ۳۳-۳۹
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عنوان انگلیسی Ficolin-A Enhances Inhibition of the C-Terminal 19 kDa Region of Merozoite Surface Protein-1 of Plasmodium berghei Using Test In Vivo.
چکیده انگلیسی مقاله Background : Malaria remains a serious public health problem with significant morbidity and mortal-ity. This study was conducted to identify whether ficolin-A could play an active role of against mala-ria infection. Methods : The function of ficolin-A was analyzed in mouse model. The open reading frame of fico-lin-A was cloned from the liver of new born C57BL/6 mice by RT-PCR and then inserted into the expression vector of eukaryon to construct pVAX1-ficolin-A plasmid. Meanwhile, the open reading frame of the 19-kDa fragment of merozoite surface protein-1 of Plasmodium berghei (MSP1 19 ) was cloned and then the expression vector of eukaryon, pVAX1- MSP1 19 was constructed. Both recom-binant vectors were used in the mouse model of infection by Plasmodium berghei. Results : pVAX1-ficolin-A alone could not significantly suppress parasite density and prolong sur-vival time of infection mice; however, when injected pVAX1-ficolin-A and pVAX1- MSP1 19 together, the percent of invasion by Plasmodium was decreased (from 43.78% to 22.23% at 10 day after infec-tion, compared to vector ) and the survival time was prolonged significantly in the infection mouse model ( P =0.01). Conclusion : Ficolin-A can enhance the immunoprotection of MSP1 19 , it implies ficolin-A may be used as immunoenhancer in the study of vaccine defending malaria.
کلیدواژه‌های انگلیسی مقاله Ficolin-A,MSP119,Plasmodium berghei
نویسندگان مقاله f chen | f chen
the faculty of life sciences, hubei university, 368 youyi road, wuchang, wuhan 430062, china


q liu | q liu
hainan provincial key laboratory of tropical medicine, pharmacy school, hainan medical college, haikou 571199, china


y xue | y xue
lab of medical engineering, college of medical technology and engineering, henan university of science and techology, luoyang 471003, china


yh هوانگ | yh huang
hainan provincial key laboratory of tropical medicine, pharmacy school, hainan medical college, haikou 571199, china


fy هوانگ | fy huang
hainan provincial key laboratory of tropical medicine, pharmacy school, hainan medical college, haikou 571199, china


y lin | y lin
hainan provincial key laboratory of tropical medicine, pharmacy school, hainan medical college, haikou 571199, china


gh tan | gh tan
hainan provincial key laboratory of tropical medicine, pharmacy school, hainan medical college, haikou 571199, china


j zhou | j zhou
wuhan tuberculosis dispensary, 28 baofeng road, qiaokou, wuhan, 430030, china fan chen and qiang liu are co-primary authors
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/529
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