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Iranian Journal of Parasitology، جلد ۸، شماره ۱، صفحات ۷۳-۷۷
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عنوان انگلیسی The Ultrastructural Effects of Sulfachloropyrazine on Toxoplasma gondii Tachyzoites.
چکیده انگلیسی مقاله Background: Toxoplasmosis is one of the most common parasitic infections of humans and other mammals. This study was aimed to understand the mechanism of action of veterinary medicine-sulfachloropyrazine (SPZ, 99.97%) against Toxoplasma gondii . Methods: T. gondii tachyzoites were soaked in PBS (as a control) or SPZ (250 mg/mL) for 2 h at 37 °C. After being processed, any ultrastructural changes of the tachyzoites that had occurred were observed by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). Results: The tachyzoites from control groups with a uniform size had a smooth surface and intact cell or nuclear membranes. In addition, an oval-shaped nucleus, conoids and micronemes were also observed. By contrast, many parasites from the SPZ-treated groups were detrimentally affected by the treatment. Some appeared to be of the vacuolization in their cytoplasm, with the substantial re-duction in the number of dense granules and the blur of some organelles. Conclusion: The morphology and ultrastructure of tachyzoites can be affected significantly by SPZ, which might kill the parasite by inhibiting its energy metabolism, inducing apoptosis and damaging its structure . The study provides an experimental basis for further study on the mechanism of SPZ against T. gondii .
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نویسندگان مقاله yb زنگ | yb zeng
key laboratory for animal parasitology of ministry of agriculture, shanghai veterinary research institute, chinese academic of agricultural science, shanghai 200241, china.


h دانک | h dong
key laboratory for animal parasitology of ministry of agriculture, shanghai veterinary research institute, chinese academic of agricultural science, shanghai 200241, china.


hy هانیه | hy han
key laboratory for animal parasitology of ministry of agriculture, shanghai veterinary research institute, chinese academic of agricultural science, shanghai 200241, china.


ll jiang | ll jiang
key laboratory for animal parasitology of ministry of agriculture, shanghai veterinary research institute, chinese academic of agricultural science, shanghai 200241, china.


qp zhao | qp zhao
key laboratory for animal parasitology of ministry of agriculture, shanghai veterinary research institute, chinese academic of agricultural science, shanghai 200241, china.


sh zhu | sh zhu
key laboratory for animal parasitology of ministry of agriculture, shanghai veterinary research institute, chinese academic of agricultural science, shanghai 200241, china.


wj ma | wj ma
key laboratory for animal parasitology of ministry of agriculture, shanghai veterinary research institute, chinese academic of agricultural science, shanghai 200241, china.


j چنگ | j cheng
key laboratory for animal parasitology of ministry of agriculture, shanghai veterinary research institute, chinese academic of agricultural science, shanghai 200241, china.


b هوانگ | b huang
key laboratory for animal parasitology of ministry of agriculture, shanghai veterinary research institute, chinese academic of agricultural science, shanghai 200241, china.
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/523
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