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Iranian Journal of Parasitology، جلد ۸، شماره ۱، صفحات ۹۹-۱۰۶
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عنوان انگلیسی Evaluation of Cross Immunity and Histopathological Findings in Experimentally Infected BALB/c Mice with Neospora caninum and Besnoitia caprae.
چکیده انگلیسی مقاله Background: Caprine besnoitiosis is an economically important disease of goats. Neospora caninum, another coccidian parasite of worldwide distribution, infects several animal species and is a major cause of abortion in cattle . Combined infections of N. caninum and Besnoitia caprae can occur in geo-graphical areas endemic for both species of parasite in goats. This experiment was conducted to in-vestigate the possible cross-immunity between these two infections in experimentally infected BALB/c mice. Methods: Forty BALB/c mice were divided into four equal groups. The mice of Groups 1 and 4 were inoculated with 1×10 6 live virulent tachyzoites of N. caninum (NC-1), while animals of Groups 2 and 3 were inoculated with sterile tissue culture medium. Each mouse in Groups 1 and 2 was chal-lenged 28 days later with 1×10 6 live virulent bradyzoites of B. Caprae (BC-1). Results: Following the challenge, the mice in Groups 1 and 2 showed 100% morbidity and 100% mortality within 9 days post infection, while all the animals of Groups 3 and 4 remained alive. The dead animals were necropsied. The survivors (mice in Group 3 and 4) were euthanized 9 days after inoculation and the gross and histopathological lesions in different organs were investigated. Conclusion: Immunization and challenge experiments with lethal dose of B. caprae in the highly sus-ceptible BALB/c mice showed no cross-protection between N. caninum and B. caprae .
کلیدواژه‌های انگلیسی مقاله BALB/c mice,Besnoitia caprae,Cross reaction,Neospora caninum
نویسندگان مقاله m نام آوری | m namavari
razi vaccine and serum research institute, shiraz, iran.

سازمان اصلی تایید شده: موسسه تحقیقات واکسن و سرم سازی رازی (Razi vaccine and serum research institute)

a عریان | a oryan
department of pathology, school of veterinary medicine, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

f نمازی | f namazi
department of pathology, school of veterinary medicine, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

کارگر | m kargar
department of pathology, school of veterinary medicine, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

m منصوریان | m mansourian
razi vaccine and serum research institute, shiraz, iran.

سازمان اصلی تایید شده: موسسه تحقیقات واکسن و سرم سازی رازی (Razi vaccine and serum research institute)

a رحیمیان | a rahimian
razi vaccine and serum research institute, shiraz, iran.

سازمان اصلی تایید شده: موسسه تحقیقات واکسن و سرم سازی رازی (Razi vaccine and serum research institute)

y تهمتن | y tahamtan
razi vaccine and serum research institute, shiraz, iran.

سازمان اصلی تایید شده: موسسه تحقیقات واکسن و سرم سازی رازی (Razi vaccine and serum research institute)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/519
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