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Iranian Journal of Parasitology، جلد ۷، شماره ۲، صفحات ۸-۱۴
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عنوان انگلیسی In vivo Susceptibility of Plasmodium vivax to Chloroquine in Southeastern Iran
چکیده انگلیسی مقاله Background: Plasmodium vivax is the predominant species causes of malaria with about 90% total annual reported malaria in Iran. This study conducted to determine the susceptibility of Plasmodium vivax isolates to chloroquine in Sistan and Balochistan Province, southeastern Iran. Methods: A total 270 subjects with symptomatic malaria and confirmed P. vivax infection completed the designed 28-day in vivo study. The thick and thin film blood smears were screened for malaria parasites by microscopy. The nested PCR was applied using the Plasmodium 18 subunit ribosomal ribonu­cleic (Ssr RNA) genes for detecting mixed infections and diagnosis of parasites in the samples with low parasite on days 0, 5, 6, 7, and 28. Results: P. vivax was cleared in 15%, 50%, 95%, and 100% of patients on days 1, 2, 3, 4 respectively by microscopy assessment. Six patients were exhibited specific P. vivax band in nested PCR on day 5. No recurrence was observed on days 7, 14 and 28. Mean (±standard deviation) parasite clearance time was 2.41 (±0.8) days. Conclusion: P. vivax is still susceptible to chloroquine in Southeatern Iran. This finding is compati­ble with results of neighboring countries Pakistan and Afghanistan.
کلیدواژه‌های انگلیسی مقاله Malaria,Plasmodium vivax,Chloroquine,Iran
نویسندگان مقاله علی حیدری | a heidari
dept. of pathobiology, school of medicine, alborz university of medical sciences, karaj, iran


h کشاورز | h keshavarz
dept. of medical parasitology and mycology, school of public health, tehran university of medical sciences, tehran, iran and center for research of endemic parasites of iran crepi , tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

s شجاعی | s shojaee
dept. of medical parasitology and mycology, school of public health, tehran university of medical sciences, tehran, iran and center for research of endemic parasites of iran crepi , tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

a رییسی | a raeisi
dept. of medical entomology and vector control, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

s dittrich | s dittrich
molecular biology laboratory lao oxford mahosotwelcome trust research unit, vientaine, laopdr
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/230
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