این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Parasitology، جلد ۷، شماره ۲، صفحات ۲۱-۲۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Inhibition of Murine Systemic Leishmaniasis by Acetyl Salicylic Acid via Nitric Oxide Immunomodulation
چکیده انگلیسی مقاله Background: The purpose of this study was to evaluate antileishmanial effects of ASA via NO pathway in Leishmania major infected Balb/c mice. Moreover, toxicity and pathological consequences of ASA administration were investigated. Methods: Balb/c mice were infected with L. major and ASA was inoculated orally after lesion appearance for its ability to modulate NO and to modify Leishmania infection in host, in order to evaluate the effects of NO production on size and lesion macroscopy, delay of lesion formation and proliferation of amasti­gotes inside macrophages. Liver, spleen, and lymph nodes were also studied as target organs to detect amastigotes. In addition, plasma was investigated for NO induction using Griess microassay. Results: ASA increased NO production in plasma of both naïve and Leishmania test groups at the ultimate of the experimental period. A decline was observed in proliferation of amastigotes inside macrophages of test group when compared with control one. ASA reduced lesion size, inhibited Leishma­nia visceralisation in spleen, lymph node, and decreased hepato/splenomegaly in ASA treated animals. Conclusions : Some antileishmanial effects of ASA by NO-modulation were indicated during systemic leishmaniasis in mice. Despite slight effects on lesion size, ASA decreased parasite visceralization in target organs and declined their proliferation inside macrophages. Therefore, ASA may be indicated to inhibit systemic leishmaniasis via NO pathway in mice model.
کلیدواژه‌های انگلیسی مقاله ASA, Balb/c,Leishmania major,Immunotherapy
نویسندگان مقاله h نهروانیان | h nahrevanian
department of parasitology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

m جلالیان | m jalalian
department of microbiology, islamic azad university of lahijan, gilan, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی لاهیجان (Islamic azad university of lahijan)

m فرهمند | m farahmand
department of parasitology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

m آسمار | m assmar
department of microbiology, islamic azad university of lahijan, gilan, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی لاهیجان (Islamic azad university of lahijan)

ar اسماعیلی رستاقی | ar esmaeili rastaghi
department of parasitology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

m سیاح | m sayyah
department of physiology amp;amp; pharmacology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/232
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات