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Iranian Journal of Parasitology، جلد ۶، شماره ۴، صفحات ۶۰-۷۵
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عنوان انگلیسی Leishmania mexicana Gp63 cDNA Using Gene Gun Induced Higher Immunity to L. mexicana Infection Compared to Soluble Leishmania Antigen in BALB/C
چکیده انگلیسی مقاله Background: Leishmaniasis is a worldwide disease prevalent in tropical and sub tropical coun­tries. Many attempts have been made and different strategies have been approached to develop a potent vaccine against Leishmania . DNA immunisation is a method, which is shown to be effec­tive in Leishmania vaccination. Leishmania Soluble Antigen (SLA) has also recently been used Leishmania vaccination. Methods: The immunity generated by SLA and L. mexicana gp63 cDNA was compared in groups of 6 mice, which were statistically analysed by student t - test with the P -value of 0.05. SLA was administered by two different methods; intramuscular injection and injection of den­dritic cells (DCs) loaded with SLA. L. mexicana gp63 cDNA was administered by the gene gun. Results: Immunisation of BALB/c mice with L. mexicana gp63 resulted in high levels of Th1-type immune response and cytotoxic T lymphocytes (CTL) activity, which were accompanied with protection induced by the immunisation against L. mexicana infection. In contrast, administra­tion of SLA, produced a mixed Th1/Th2-type immune responses as well as a high level of CTL activity but did not protect mice from the infection. Conclusion: The results indicate higher protection by DNA immunisation using L. mexicana gp63 cDNA compared to SLA, which is accompanied by a high level of Th1 immune response. However, the CTL activity does not necessarily correlate with the protection induced by the vac­cine. Also, gene gun immunisation is a potential approach in Leishmania vaccination. These find­ings would be helpful in opening new windows in Leishmania vaccine research.
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نویسندگان مقاله h رضوان | h rezvan
department of laboratory science, school of paraveterinary sciences, bu-ali sina university, hamedan, iran

سازمان اصلی تایید شده: دانشگاه بوعلی سینا (Bu ali sina university)

r ریز | r rees
school of science and technology, nottingham trent university, clifton, nottingham, uk, ng11 8ns


sa علی | sa ali
school of science and technology, nottingham trent university, clifton, nottingham, uk, ng11 8ns
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/206
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