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Iranian Journal of Parasitology، جلد ۶، شماره ۲، صفحات ۹-۱۶
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عنوان انگلیسی Apoptosis of Human Lymphocytes after Exposure to Hydatid Fluid
چکیده انگلیسی مقاله Background: Modulation of the immune response is an important strategy by which establish­ment and growth of hydatid cyst in the internal organs of human is warranted. Induction of apop­tosis in the lymphocytes might be a considerable component. This study was designed to evaluate apoptotic impact of hydatid fluid (HF) on human lymphocytes. Methods: Human lymphocytes were treated with hydatid fluid. After 6 hours of exposure, cas­pase-3 activity, the central enzyme of apoptosis cascade, was measured by fluorometric assay in the HF-treated lymphocytes and control cells. In addition, the expression of Bax (a pro-apoptotic protein) and Bcl-2 (an anti-apoptotic protein) mRNA was assessed by RT-PCR after 12 hours of exposure. Results: Both the ratio of Bax/Bcl-2 mRNA expression and Caspase-3 activity were higher in the HF-treated lymphocytes relative to the control group. Conclusion: Apoptosis could be as a possible mechanism by which Echinococcus granulosus overwhelms host defenses.
کلیدواژه‌های انگلیسی مقاله Hydatidosis,Fertile/Infertile Hydatid Cysts,Apoptosis
نویسندگان مقاله m مختاری امیرمجدی | m mokhtari amirmajdi
department of mycoparasitology, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

m سنکیان | m sankian
immunobiochemistry laboratory, immunology research center, bu-ali research institute, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

i افتخارزاده مشهدی | i eftekharzadeh mashhadi
department of mycoparasitology, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

وارسته | a varasteh
immunobiochemistry laboratory, immunology research center, bu-ali research institute, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

f واحدی | f vahedi
immunobiochemistry laboratory, immunology research center, bu-ali research institute, school of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

a صدری زاده | a sadrizadeh
department of thoracic surgery, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

عادل | a spotin
department of mycoparasitology, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/173
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