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Iranian Journal of Parasitology، جلد ۵، شماره ۱، صفحات ۶-۱۹
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عنوان انگلیسی In Vivo Antimalarial Effects of Iranian Flora Artemisia khorassanica against Plasmodium berghei and Pharmacochemistry of its Natural Components
چکیده انگلیسی مقاله Background : The aim of this study was to evaluate the antimalarial effects of Iranian flora Artemisia khorassanica against Plasmodium berghei in vivo and pharmacochemistry of its natural components. Methods : The aerial parts of Iranian flora A. khorasanica were collected at flowering stage from Khorassan Province, northeastern Iran in 2008. They were air-dried at room temperature; powder was macerated in methanol and the extract defatted in refrigerator, filtered, diluted with water, then eluted with n-hexane and finally non-polar components were identified through Gas Chromatography and Mass Spectroscopy (GC-MS). Toxicity of herbal extracts was assessed on naïve NMRI mice, and its anti-malarial efficacy was investigated on infected Plasmodium berghei animals. This is the first ap­plication on A. khorssanica extract for treatment of murine malaria. The significance of differences was determined by Analysis of Variances (ANOVA) and Student's t -test using Graph Pad Prism Software. Results : The herbal extract was successfully tested in vivo for its anti-plasmodial activity through ar­temisin composition, which is widely used as a standard malaria treatment. Conclusion : Although, this study confirmed less anti-malarial effects of A. khorssanica against mur­ine malaria in vivo , how­ever there are some evidences on reducing pathophysiology by this medica­tion. In complementary assay, major components were detected by GC-MS analysis in herbal extract including chrysanthe­none (7.8%), palmitic acid (7.4%) and cis-thujone (5.8%). The most retention indices of the compo­nent are given as n-eicosane, palmitic acid and n-octadecane.
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نویسندگان مقاله h نهروانیان | h nahrevanian
department of parasitology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

b کاظمی | b kazemi
payame nour university, tehran center, tehran, iran


m ناظم | m nazem
department of applied chemistry, islamic azad university, qom branch, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

h ناظم | h nazem
payame nour university, tehran center, tehran, iran


محمد امینی | m amini
department of parasitology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/121
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