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Iranian Journal of Parasitology، جلد ۳، شماره ۴، صفحات ۳۲-۳۸
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عنوان انگلیسی In Vitro Antiamoebic Activity of Iranian Allium sativum in Comparison With Metronidazole against Entamoeba histolytica
چکیده انگلیسی مقاله Background: Amoebiasis is due to infection with the protozoan parasite Entamoeba histolytica. The patients infected with E. histolytica must be treated right after definite diagnosis and no need to treat infected individuals with E. dispar isolates. Metronidazole is used as a drug of choice against amoebiasis. However, like a lot of other chemical agents, this drug has its own side effects. This prompted us to carry out, an in vitro research into antiamoebic effect of Iranian Allium sativum (gar­lic), which has been used for centuries, as an herbal medicine, without harmful side effects. Methods: Hydro-alcoholic, hexanic extracts and essential oil of 100 gram of crushed A. sativum was isolated and the minimal inhibitory concentration (MIC) of the extracts and essential oil in comparison with metronidazole were obtained on trophozoite of E. histolytica, HM-1: IMSS strain in TYI-S-33 medium. Results: The MIC for A. sativum hydroalcoholic, hexanic extracts and essential oil after 24 hours was 60mg mL -1 , 4mg mL -1 and 0.4mg mL -1 , respectively. After 48 hours the MIC for A. sativum hexanic extract and essential oil was 3mg mL -1 and 0.3mg mL -1 , respectively. MIC for metronidazole was obtained 2μg mL -1 and 1.5μg mL -1 after 24 hours and 48 hours, in that order. Conclusion: Iranian A. sativum is effective on the trophozoites of E. histolytica species and the essential oil exhibited the greatest antiamoebic activity, at the lowest MIC.
کلیدواژه‌های انگلیسی مقاله Entamoeba histolytica, Allium sativum, Antiamoebic
نویسندگان مقاله m بهنیا | m behnia
laboratory complex, science and research branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

a حقیقی | a haghighi
dept. of parasitology and mycology, school of medicine, shahid beheshti university medical campus ,

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

h کمیلی زاده | h komeilizadeh
dept. of medicinal chemistry, school of pharmacy, shahid beheshti university medical campus , tehra

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

sj سید طبایی | sj seyyed tabaei
dept. of parasitology and mycology, school of medicine, shahid beheshti university medical campus ,

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

a آبادی | a abadi
dept. of health and social medicine, school of medicine, shahid beheshti university medical campus

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/77
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