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Journal of Injury and Violence Research، جلد ۶، شماره ۲، صفحات ۷۲-۰
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عنوان انگلیسی Role of phosphodiesterase inhibitor Ibudilast in morphine-induced hippocampal injury
چکیده انگلیسی مقاله BACKGROUND: Opioid drugs are used in the treatment of acute post-surgical pain and chronic pain, such as those associated with cancer. Opioid used is associated with complications such as analgesic tolerance, dependence and opioid abuse . The molecular mechanisms of unwanted opioid responses are varied but recent advances have highlighted elevations in pro-inflammatory cytokines and pro-inflammatory glial following chronic administration of morphine. In this study we investigated the neurodegenerative effects of morphine through its effects on Toll-Like Receptor 4 (TLR4) in the male rat hippocampus and evaluated the level of Interleukin-1 beta (IL-1 β ). Then we compared the difference between inhibitory effects on mu opioid receptors (by β -Funaltrexamine, β -FNA) and TLR4 (by Ibudilast). Subsequently, we assessed the amount of IL-1 β and the number of granular cells in male rat hippocampus. METHODS: Adult male rats (n=24) were treated with sucrose, morphine, Ibudilast (7.5 mg/kg) and β -FNA (20 mg/kg) for 30 days. Their brains were isolated and hemisected with one hippocampus for granular cell and the other used for IL-1 β immunoblotting. RESULTS: Data showed that Ibudilast suppresses IL-1 β expression significantly more than β -FNA. The granular cell count displayed significant differences. CONCLUSIONS: Our results suggested that Ibudilast can be used for controlling and treatment of morphine-induced CNS inflammations or traumatic conditions. © 2013 KUMS, All rights reserved
کلیدواژه‌های انگلیسی مقاله TLR4,Morphine,Ibudilast,Inflammation,Innate Immunity
نویسندگان مقاله محسن ژاله | mohsen zhaleh


مرضیه پناهی | marzieh panahi


مهری غفوریان بروجردنیا | mehri ghafurian broujerdnia


رستم قربانی | rostam ghorbani


کامبیز احمدی انگالی | kambiz ahmadi angali


قاسم ساکی | ghasem saki


نشانی اینترنتی http://jivresearch.org/jivr/index.php/jivr/article/view/497
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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