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Journal of Arthropod-Borne Diseases، جلد ۱۰، شماره ۲، صفحات ۱۲۷-۱۴۰
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عنوان انگلیسی Genetic Diversity of Crimean Congo Hemorrhagic Fever Virus Strains from Iran
چکیده انگلیسی مقاله Background: Crimean Congo hemorrhagic fever virus (CCHFV) is a member of the Bunyaviridae family and Nairovirus genus. It has a negative-sense, single stranded RNA genome approximately 19.2 kb, containing the Small, Medium, and Large segments. CCHFVs are relatively divergent in their genome sequence and grouped in seven distinct clades based on S-segment sequence analysis and six clades based on M-segment sequences. Our aim was to obtain new insights into the molecular epidemiology of CCHFV in Iran. Methods: We analyzed partial and complete nucleotide sequences of the S and M segments derived from 50 Iranian patients. The extracted RNA was amplified using one-step RT-PCR and then sequenced. The sequences were ana­lyzed using Mega5 software. Results: Phylogenetic analysis of partial S segment sequences demonstrated that clade IV-(Asia 1), clade IV-(Asia 2) and clade V-(Europe) accounted for 80 %, 4 % and 14 % of the circulating genomic variants of CCHFV in Iran respectively. However, one of the Iranian strains (Iran-Kerman/22) was associated with none of other sequences and formed a new clade (VII). The phylogenetic analysis of complete S-segment nucleotide sequences from selected Ira­nian CCHFV strains complemented with representative strains from GenBank revealed similar topology as partial sequences with eight major clusters. A partial M segment phylogeny positioned the Iranian strains in either associa­tion with clade III (Asia-Africa) or clade V (Europe). Conclusion: The phylogenetic analysis revealed subtle links between distant geographic locations, which we pro­pose might originate either from international livestock trade or from long-distance carriage of CCHFV by infected ticks via bird migration.
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نویسندگان مقاله صادق چینی کار | sadegh chinikar
arboviruses and viral hemorrhagic fevers laboratory national reference laboratory , pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

سعید بوذری | saeid bouzari
department of molecular biology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

محمد علی شکرگزار | mohammad ali shokrgozar
national cell bank of iran, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

احسان مصطفوی | ehsan mostafavi
department of epidemiology, pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

تهمینه جلالی | tahmineh jalali
arboviruses and viral hemorrhagic fevers laboratory national reference laboratory , pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

سحر khakifirouz | sahar khakifirouz
arboviruses and viral hemorrhagic fevers laboratory national reference laboratory , pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

نوربت nowotny | norbert nowotny
institute of virology, department of pathobiology, university of veterinary medicine, vienna, austria


آنتونی r fooks | anthony r fooks
animal health and veterinary laboratories agency, wildlife zoonoses and vector-borne diseases research group, weybridge, new haw, addlestone, surrey, united kingdom


نریمان شاه حسینی | nariman shah hosseini
arboviruses and viral hemorrhagic fevers laboratory national reference laboratory , pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

نشانی اینترنتی http://jad.tums.ac.ir/index.php/jad/article/view/142
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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