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Acta Medica Iranica، جلد ۵۵، شماره ۴، صفحات ۲۳۳-۲۴۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Assessing the Efficacy of Second-Line Antiretroviral Treatment for HIV Patients Failing First-Line Antiretroviral Therapy in IRAN: A Cohort Study
چکیده انگلیسی مقاله There are limited documents about HIV patients switched to second-line antiretroviral therapy (ART) in resource-limited countries. We aimed to assess the efficacy of second-line ART for HIV patients following first-line ART failure. This was a cohort study of HIV/AIDS patients with first-line ART treatment failure switched to second-line ART between January 2004 and March 2014, who followed for at least 12 months after switching. Fifty of studied patients (85%) were treated with regimens containing lopinavir/ritonavir (Kaletra) and nine of them (15%) treated with other regimes. Seven patients were experienced opportunistic infections in accordance with stage III and IV WHO classification. In this way, 11.8% of patients had aclinicalfailure, and 37 of them (62%) had immunological responses. Weight gain was evident in these patients, and there was a significant correlation between theincrease in CD4 and weight gain ( P =0.007). Only 13 patients achieved HIV viral load testing that 6 of them had avirological response after 12 months on second-line ART. No significant associations were found between virological or immunological response and gender, age, and lopinavir/ritonavir regimens ( P >0.05).With counselling and supporting in those failing first-line ART, inessential switching to more costly second-line ART can be prevented in the majority of patients. However, patients' need to second-line ART drugs has increased, for which national ART programmes and regular follow-up should be organized. The high cost of these drugs and limited access to viral load testing are main barriers to proper management of patients switched to second-line ART regimens.
کلیدواژه‌های انگلیسی مقاله Antiretroviral therapy,HIV,Cohort studies,Iran
نویسندگان مقاله مهرناز رسولی نژاد | mehrnaz rasooli nejad
iranian research center for hiv aids, iranian institute for reduction of high-risk behaviors, tehran university of medical sciences, tehran, iran. and department of infectious diseases, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مریم خزایی پول | maryam khazaee pool
department of health education and promotion, school of public health, zanjan university of medical sciences, zanjan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

لادن عباسیان | ladan abbasian
iranian research center for hiv aids, iranian institute for reduction of high-risk behaviors, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

زهرا بیات جوزانی | zahra bayat jozani
iranian research center for hiv aids, iranian institute for reduction of high-risk behaviors, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سارا احسنی نسب | sara ahsani nasab
1iranian research center for hiv aids, iranian institute for reduction of high-risk behaviors, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بنفشه مرادمند بدیع | banafsheh moradmand badie
discipline of public health, school of medicine, flinders university, south australia.


افسانه پرگر | afsaneh pargar
iranian research center for hiv aids, iranian institute for reduction of high-risk behaviors, tehran university of medical sciences, tehran, iran. and department of infectious diseases, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

غلامرضا اسماعیلی جاوید | gholamreza esmaeeli djavid
academic member of academic center for education, culture and research, tehran, iran.
نشانی اینترنتی http://acta.tums.ac.ir/index.php/acta/article/view/5060
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/56/article-56-398169.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Articles
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