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Journal of Arthropod-Borne Diseases، جلد ۴، شماره ۱، صفحات ۲۴-۳۰
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عنوان انگلیسی Molecular Monitoring of Plasmodium vivax Infection afterRadical Treatment in Southeastern Iran
چکیده انگلیسی مقاله Background: The aim was to evaluate the relapse risk of vivax malaria in patients who received radical treatment in Hormozgan Province, a malarious area located on southeast of Iran. Methods: A total of 95 symptomatic vivax malaria infected patients were enrolled in urban health centers of Bandar - Abbas, Minab, Bandar-Jask and Bashagard districts of Hormozgan Province, southeast of Iran from January 2008 to March 2009 for consideration as a case- series study. DNA was extracted from parasite infected whole blood samples. A polymorphic region of Plasmodium vivax merozoite surface protein 1 (pvMSP1) was selected and a PCR method was employed for all the samples to amplify the specific variable gene fragment. The obtained fragments in primary and secondary samples were sequenced. Both nucleotide and amino acid sequences of the samples were investigated for returned patients. Results: 3.2% of the patients experienced a second attack between 83-199 days after the initial episode of infection . Alignment of nucleotide and their deduced amino acid sequences between pair sequences of primary and secondary isolates revealed 8 and 6 dissimilarities respectively for the first case, and 9 and 7 dissimilarities for the second case. Although microscopical examination of recurrent thick blood smear of the third patient confirmed new P. vivax infection, the venous blood sample was accidentally missed. Sequencing results of primary and returned isolates 1P, 1S, 2P, 2S and 3P in this study showed an identity with BP13, T117, BP13, TC28 and Chesson genotypes respectively. Conclusion: The returned (secondary) isolates may account to be for the sake of reinfection.
کلیدواژه‌های انگلیسی مقاله P.vivax, relapse, re-infection, recrudescence, pvMSP1, Iran
نویسندگان مقاله m ناطق پور | m nateghpour
department of parasitology and mycology, school of public health, tehran university of medical sciences, iran and national institute of health research

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

s ایازیان ماوی | s ayazian mavi
department of parasitology and mycology, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

h کشاورز | h keshavarz
department of parasitology and mycology, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

رضایی | s rezaei
department of parasitology and mycology, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عابدی | f abedi
hormozgan university of medical sciences, bandar abbas, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی هرمزگان (Hormozgan university of medical sciences)

gh ادریسیان | gh edrissian
department of parasitology and mycology, school of public health, tehran university of medical sciences, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

r رییسی | r raeisi
center of infectious disease management, ministry of health, treatment and medical education, tehran, iran
نشانی اینترنتی http://jad.tums.ac.ir/index.php/jad/article/view/58
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