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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲۰۱۵، شماره ۱۰، صفحات ۰-۰
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عنوان انگلیسی Correlation between glycemic and zinc status in with beta-thalassemia major
چکیده انگلیسی مقاله Objective : To assess the glucose tolerance in patients with beta thalassemia major and association of Homeostasis Model Assessment (HOMA) parameters with zinc status in these patients. Methods: in this cross-sectional study, Clinical data of patients with thalassemia major, aged ≥10 years were collected. Serum ferritin concentration, fasting plasma glucose, fasting plasma insulin and serum zinc level were measured after overnight fasting. Oral glucose tolerance test was performed. Beta cell function, insulin sensitivity and insulin resistance were calculated for normoglycemic and prediabetic participants using the Homeostasis Model Assessment (HOMA-2) calculator. Results: One hundred sixty three patients with beta thalassemia major were included in the study. Of 163 participants, 37% were normal, 53% had prediabetes and 10% had diabetes. The mean serum zinc concentration was 18.90±10.93μg/dl. Serum zinc was found to be similar across patients with prediabetes, diabetes and normal patients. Beta cell function was significantly lower in subjects with prediabetes than normal participants (P= 0.0001). An inverse relation was documented between beta cell function on one hand, and total units of blood transfusion and ferritin level on the other (r=-0.29, P=0.004 and r= -0.27, P=0.03 respectively). After adjusting for multiple possible confounders in normal and patients with prediabetes, this analysis did not show any significant association of HOMA parameters with serum zinc level. Conclusion : Impaired glucose metabolism is extremely frequent in our patients and Low serum zinc level is common in these patients. This signifies the importance of follow-up for early detection and appropriate therapy. No relationship between HOMA parameters and serum zinc level was noted.
کلیدواژه‌های انگلیسی مقاله Zinc , Beta thalassemia Major, Diabetes mellitus
نویسندگان مقاله محمد علی مشهدی | mohammad ali mashhadi


زهرا سپهری | zahra sepehri


زهرا حیدری | zahra heidari


محمود رضا کیخوایی | mahmoud reza kaykhaei


عذرا کریم کشته | azra karimkoshte


هانیه حیدری | hanieh heidari


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/595
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