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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲۰۱۵، شماره ۱۰، صفحات ۰-۰
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عنوان انگلیسی Familial colorectal cancer type X in Central Iran: a new clinicopathologic description
چکیده انگلیسی مقاله Objectives: Familial colorectal cancer type X (FCCX) is a subtype of mismatch-repair (MMR) proficient colorectal cancer which the patients are clinically at risk for Lynch syndrome (LS), a common hereditary cancer predisposing syndrome. We describe a new clinicopathological feature of the condition in Central Iran. Methods: We designed a descriptive retrospective study to screen at-risk colorectal cancer (CRC) patients using Amsterdam II criteria and Molecular analysis in Isfahan (central Iran) within 2000-2013. Results: We could contact with 219 early-onset (≤ 50 years) CRC patients of all 1659 patients. Amsterdam II criteria were positive in 45 families of which 31 families were finally analyze by molecular testing. MMR deficiency was detected in 7/31 probands (22.6%) as affected to LS, so 24 families (77.4%) were identified as FCCX. The mean age of the probands at diagnosis among FCCX families was 45.3 years (range 24-69) versus 38.0 years (range 31-50) in LS families. The frequency of CRC among FCCX and LS families was calculated 27.9% and 67.5%, respectively. Also the most frequent extracolonic cancer among both FCCX and LS families was stomach by 25.5% and 30.8%, respectively. Tumor site was proximal to the splenic flexure in 20.8% and 57.1% of index CRC patients in FCCX and LS families, respectively. Conclusions: Given the relative high frequency of FCCX and its different phenotype among Iranian populations, we need to set up more advanced molecular studies for exploration of unknown molecular pathways leading to tumorigenesis in this class of CRC patients. 
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نویسندگان مقاله مهرداد زینلیان | mehrdad zeinalian


مهدی هادیان | mahdi hadian


مرتضی هاشم زاده چالشتری | morteza hashemzadeh chaleshtori


رسول صالحی | rasoul salehi


محمد حسن امامی | mohammad hassan emami


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/658
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