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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲۰۱۵، شماره ۱۰، صفحات ۰-۰
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عنوان انگلیسی Is There any Concordance Between of IHC with FISH in Her-2 Positive Breast Cancer Patients?
چکیده انگلیسی مقاله Background : Breast cancer is the most common cancer and common cause of death (16%) which occurs due to cancers among women, either in developed or developing countries. Herein, we compared hormone receptors and HER2 with each other and with FISH in patients with breast cancer, and affection of trastuzumab on disease free survival and overall survival (OS). Material and Methods: Immunohistochemical (IHC) analysis of hormone receptors and HER2 was performed in 133 patients of breast cancer between of 2003 to 2014. Patients were selected for Herceptin adjuvant treatment according to IHC3+ or FISH+. The specimens for pathology reports were fixed in 10% neutral-buffered formalin (pH=7.4) for 24 hours, then sliced into 4- μ m sections. Results : The mean age of patients at diagnosis was 46.39 years (range, 24-78 years), 100% female. Concordance rates between IHC and FISH were 31.1% for IHC 2+ and 84.1% for IHC 3+ (P< 0.001). The 87 patients had age ≤50 years and 46 patients had >50 years. Of the 133 patients, 30 patients (22.6%) had metastasis and 72(54.1%) had right involvement. 93(69.9%) patients had lymph node invasive. 48 patients (36.1%) were treated with trastuzumab and 85(63.9%) were treated without trsastuzumab. The 10-year survival rate was 70% and the mean survival was 49 months. Conclusions : We advise clinicians that FISH analysis is as a predictive in breast cancer patients with IHC score 2+. In contrast, FISH analysis for IHC3+ samples was no useful. Trastuzumab therapy is effective and tolerated for breast cancer with IHC3+ and probably IHC2+/FISH+.
کلیدواژه‌های انگلیسی مقاله FISH,Hormone Receptors,DFS,Trastuzumab
نویسندگان مقاله مهرداد پاینده | mehrdad payandeh
cancer research center, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

مسعود صادقی | masoud sadeghi
medical biology research center, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

ادریس صادقی | edris sadeghi
cancer research center, kermanshah university of medical sciences, kermanshah, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/534
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