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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۰، شماره ۴، صفحات ۲۱۲-۲۱۶
عنوان فارسی
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عنوان انگلیسی Evaluation of Outcome and Tolerability of Combination Chemotherapy with Capecitabine and Oxaliplatin as First Line Therapy in Advanced Gastric Cancer
چکیده انگلیسی مقاله Background: Combination chemotherapy is accepted as a high efficacy treatment for gastric cancer, whereas choice of standard treatment is unclear. Multiple chemotherapeutic regimens have been used to achieve higher efficacy and lower toxicity. This study was designed to evaluate the treatment results of advanced gastric cancer with Capecitabine and Oxaliplatin regimen. Subjects and Methods : All cases with documented gastric adenocarcinoma and advanced disease were candidates for receiving Xelox regimen (Capecitabine – 750 mg/m 2 /twice daily/ 1-14 days and Oxaliplatin 125 mg/m 2 in 1st day). Results: Twenty five cases with advanced gastric cancer entered in study while 24 cases continued treatment protocol and were evaluated. Mean age was 59.5 ± 12.1 years (range: 20-75), male and female cases were 66.7% and 33.3%, respectively. All cases received at least four cycles of Xelox regimen. Overall response rate was 74.99% with 29.16% complete response. Overall survival rate was 13 ± 0.53 months and DFS (disease-free survival) was 6 ± 1.09 months. Extremities neuropathy (62.5%), headache (45.8%) and muscle cramps (29.2%) were the most common complains. Haematological changes were rare and 16.7% of cases had mild cytopenia. Treatment related death was not observed. Conclusion: Xelox regimen is a safe and highly effective first line treatment for gastric cancer; however, considering it as first line therapy needs larger studies.
کلیدواژه‌های انگلیسی مقاله Advanced gastric cancer, Capecitabine, Oxaliplatin
نویسندگان مقاله محمد علی مشهدی | mohammad ali mashhadi
professor, health promotion research center, zahedan university of medical sciences, zahedan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

زهرا سپهری | zahra sepehri
assistant professor of internal medicine, department of internal medicine, amir al-momenin hospital, zabol university of medical sciences, zabol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)

علی رضا بخشی پور | ali reza bakhshipour
associate professor, department of internal medicine, ali-ebne abitaleb hospital, zahedan university of medical sciences, zahedan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

علی زیوری | ali zivari
assistant professor, department of internal medicine, ali-ebne abitaleb hospital, zahedan university of medical sciences, zahedan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

حسین علی دانش | hossein ali danesh
assistant professor of surgical medicine, department of surgical medicine, ali-ebne abitaleb hospital, zahedan university of medical sciences, zahedan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

حسن علی متانت | hasan ali metanat
assistant professor, department of internal medicine, ali-ebne abitaleb hospital, zahedan university of medical sciences, zahedan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

عذرا karimkoshteh | azra karimkoshteh
assistant professor, department of internal medicine, ali-ebne abitaleb hospital, zahedan university of medical sciences, zahedan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

سید مهدی هاشمی | seyed mehdi hashemi
professor, health promotion research center, zahedan university of medical sciences, zahedan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)

حسین رحیمی | hossein rahimi
assistant professor of internal medicine, department of internal medicine, ghaem hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

زهره کیانی | zohre kiani
student research committee, zabol university of medical sciences, zabol, iran student research committee, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/479
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