| چکیده انگلیسی مقاله |
Background: Thalassemia is a chronic, inherited blood disorder, which in its most severe form, causes life-threatening anemia. Thalassemia patients not only engage with difficulties of blood transfusion and iron chelating therapy but also have some social challenges and health threatening factors. There are some reports on quality of life in thalassemia patients around the world from southeast of Asia to Italy in Europe and United States. In this study, we tried to evaluate and compare Health Related Quality of life (HRQoL) and the health utility in beta thalassemia major patients receiving different types of iron chelators and living in different socio-economical situations. Subjects and Methods: EQ-5D-3L accompanied by a Visual Analogue Scale (VAS) questionnaire was used. The respondents were patients with beta thalassemia major that were at least 12 years old selected from 3 provinces of Sistan-Blouchestan, Fars and Mazandaran. Comorbidities including heart complication, Diabetes Mellitus and Hepatitis and also types of iron chelators (oral, injection, combination of both) were also asked. Cross tab and ANOVA analysis conducted to evaluate each dimension score and health utility differences between provinces, iron chelation methods, comorbidities, age group and gender. Results: 528 patients answered the questionnaires. The health utility of patients that received oral iron chelator were 0.87 ± .01 for oral iron chelators versus 0.81 ± .01 for injection dosage form (p< 0.05). Increase in age was accompanied by decrease in health utility. Females faced more usual activity problems, anxiety and depression. Heart problems were more prevalent in males. Conclusion: This study suggests that the quality of life of beta thalassemia major patients is dependent on type of iron chelation treatment which they received, the gender they have, the comorbidities they suffer and socio-economical situations they live in. . |
| نویسندگان مقاله |
میثم سیدی فر | meysam seyedifar
pharmaceutical management and economics research center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
فرید عابدین درکوش | farid abedin dorkoosh
department of pharmacoeconomics and pharmaceutical administration, faculty of pharmacy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
امیر علی حمیدیه | amir ali hamidieh
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
مجید نادری | majid naderi
department of pediatrics hematology-oncology, ali-ebne abitaleb hospital research center for children and adolescent health [rccah], zahedan university of medical sciences, zahedan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
دکتر حسین کرمی | hossein karami
thalassemia research center, hemoglobinopathy institute, mazandaran university of medical sciences, sari, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)
مهران کریمی | mehran karimi
hematology research center, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
معصومه fadaiyrayeny | masoomeh fadaiyrayeny
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
معصومه موسوی | masoumeh musavi
4department of pediatrics hematology-oncology, ali-ebne abitaleb hospital research center for children and adolescent health [rccah], zahedan university of medical sciences, zahedan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زاهدان (Zahedan university of medical sciences)
ساناز صفایی | sanaz safaei
msc student of nursing, islamic azad university, isfahan khorasgan branch, isfahan, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
محمد مهدی احمدیان عطاری | mohammad mahdi ahmadian attari
department of traditional medicine, medicinal plants research center of barij, kashan, iran
ملوک حاجی بابایی | molouk hadjibabaie
research center for rational use of drugs, tehran university of medical sciences, tehran, iran faculty of pharmacy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
عبدل مجید چراغعلی | abdol majid cheraghali
faculty of pharmacy, university of baqiyatallah medical sciences, tehran, iran
علی اکبری ساری | ali akbari sari
department of health management and economics, school of public health, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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