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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۰، شماره ۱، صفحات ۳۰-۳۶
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عنوان انگلیسی A survey on the relationship between serum 25-hydroxy vitamin D level and tumor characteristics in patients with breast cancer
چکیده انگلیسی مقاله Background: In recent years, epidemiologic and laboratory studies have implied that vitamin D deficiency has a role in the pathogenesis of breast cancer. It has shown that vitamin D can prevent tumor progression induced by carcinogens and inhibit the carcinogenic effects of high fat diet on breast tissue and growth of tumor cells. This study aimed to evaluate serum 25-hydroxyvitamin D level and its role in relation to tumor characteristics and different stages of disease in women with breast cancer. Subject and Methods: This is a cross-sectional study on 200 patients with breast cancer at different stages of the disease. Information on age, menstrual status, BMI, and tumor characteristics were recorded. Serum 25-hydroxy vitamin D concentrations were measured by refigures dioimmunoassay (RIA). Mean and standard deviation were used to describe the data. Meanwhile, T-test and sum of squares test were used to analyze the data. P< 0.05 was considered significant. Results: Among 200 patients, 47 (23.5%) had severe vitamin D deficiency, 75 (37.5 %) had mild vitamin D deficiency and 78 (39.0 %) had sufficient vitamin D levels of serum. There was a significant correlation between low vitamin D levels and advanced stage of breast cancer, particularly in postmenopausal patients. Conclusion: It seems that lower levels of vitamin D accompany worse clinicopathologic features. Thus, treatment of vitamin D deficiency in postmenopausal patients might be of great benefits.
کلیدواژه‌های انگلیسی مقاله breast cancer,vitamin D,tumor stage,menopausal status
نویسندگان مقاله قاسم جان بابایی | ghasem janbabai
associate professor, medical oncologist-hematologist, gastrointestinal cancer research center, imam khomeini hospital , mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

رامین شکرریز | ramin shekarriz
assistant professor, medical oncologist-hematologist, gastrointestinal cancer research center, imam khomeini hospital, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

هما حسن زاده | homa hassanzadeh
internist, department of internal medicine, imam khomeini hospital, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

محسن | mohsen aarabi
assistant professor, epidemiologist, mazandaran university of medical sciences, health sciences research center, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

سیده سمانه برهانی | seyyedeh samaneh borhani
general physician, gastrointestinal cancer research center, mazandaran university of medical sciences, sari, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/508
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