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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۹، شماره ۴، صفحات ۲۱۵-۲۱۷
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عنوان انگلیسی Treatment related acute promyelocytic leukemia (t-APML) in breast cancer survivor treated with anthracycline based chemotherapy: rare case report
چکیده انگلیسی مقاله Treatment related acute myeloid leukemia (t-AML) is well documented phenomenon after chemotherapy. In this subgroup of patients acute promyelocytic leukemia (APML) due to delayed complication of using anthracycline is very rare occurrence. Very few cases are reported in world literature. We are reporting a rare case of occurrence of t-APML in cured breast cancer patient treated with doxorubicin. 43 year old female presented with triple negative early breast cancer treated initially with Right modified radical mastectomy. Pathological staging was pT2N0M0. She was treated with 6 cycle of adjuvant AC (Doxorubicin, Cyclophosphamide). After latent period of 23 months she developed symptoms of fever, weakness and generalized body ache. On further investigation she was found to have acute promyelocytic leukemia (APML). We had successfully treated t-APML with conventional 7+3 induction and subsequent consolidation with ATRA (All Trans Retinoic Acid) and arsenic trioxide. Patient was given maintenance treatment for 18 months after confirming negative PML RARA by RT PCR and declared cured. Patient is under regular surveillance in our centre.
کلیدواژه‌های انگلیسی مقاله Anthracycline,Breast cancer,t-APML
نویسندگان مقاله irappa madabhavi | irappa madabhavi
department of medical and pediatric oncology, gcri, ahmedabad, gujarat, india


gaurang مودی | gaurang modi
department of medical and pediatric oncology, gcri, ahmedabad, gujarat, india


harsha panchal | harsha panchal
department of medical and pediatric oncology, gcri, ahmedabad, gujarat, india


apurva patel | apurva patel
department of medical and pediatric oncology, gcri, ahmedabad, gujarat, india


asha anand | asha anand
department of medical and pediatric oncology, gcri, ahmedabad, gujarat, india


سونیا parikh | sonia parikh
department of medical and pediatric oncology, gcri, ahmedabad, gujarat, india
نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/371
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