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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۹، شماره ۲، صفحات ۸۰-۸۷
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عنوان انگلیسی Association between Interlukin-6 (IL-6), Interlukin-10 (IL-10) and depression in patients undergoing Hematopoietic stem cell transplantation.
چکیده انگلیسی مقاله The release of pro-inflammatory cytokines is responsible for the variety of behavioral, neuro-endocrine and neuro-chemical alterations in psychiatric condition. In this study we evaluate relation between depression and IL-6 and IL-10 in patients undergoing hematopoietic stem cell transplantation (HSCT).66 patients in this cross-sectional study from July 2013 until August 2014 for HSCT interred the study and were assessed for depression using Hospital Anxiety and Depression Scale (HADS). Serum interleukin (IL)-6, (IL)-10 and high sensitive C-reactive protein (hs-CRP) were assessed on the same time. Association between these biomarkers with depression was evaluated using SPSS version 20.A total of 66 patients with the mean age of 41.18+13.92 and 41.95+12.35 years old in non depressed and depressed group respectively were enrolled in this study. Patients with depression showed significantly higher levels of serum IL-6 and the IL-6-to-IL-10 ratio compared to patients without depression (p< 0.001).There was no statistically significant association between IL-10 and hs-CRP with depression in this group of the patients.High IL-6 level has significant association with depression in patients undergoing HSCT. In conclusion, since IL-6 can affect the outcomes after HSCT and depression was associated with increased serum IL-6 level, early identification of depression can be beneficial in these patients.
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نویسندگان مقاله ماریا توکلی اردکانی | maria tavakoli ardakani
department of clinical pharmacy, school of pharmacy and pharmaceutical sciences research center, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مریم مهرپویا | maryam mehrpooya
school of pharmacy, hamedan university of medical sciences, hamedan, iran.


مهشید مهدی زاده | mahshid mehdizadeh
taleghani bone marrow transplantation center, taleghani hospital and pediatric congenital hematologic disorders research center, shahid beheshti university of medical sciences ,tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

عباس حاجی فتحعلی | abbas hajifathali
taleghani bone marrow transplantation center, taleghani hospital, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

علیرضا عبدالهی | alireza abdolahi
vali-asr hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/390
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