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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۹، شماره ۱، صفحات ۲۶-۳۲
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عنوان انگلیسی Outcome of rapamycin therapy for post-transplant-lymphoproliferative disorder after kidney transplantation: case series.
چکیده انگلیسی مقاله Background: Post-transplant lymphoproliferative disorders (PTLD) are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as rapamycin have been explored. Methods: A detailed retrospective analysis was performed according to data collected from 13 patients with PTLD. At the time of PTLD diagnosis, immunosuppressive therapy was decreased and rapamycin administered. Overall survival, disease-free survival of patients and graft survival were determined. Results: Among 590 kidney transplant recipients, 13 adult patients with PTLD were included in this study. The mean age of the patients was 42.15 (range: 25-58) years at the time of PTLD diagnosis, and 9 patients were male. Histology was distributed in 9 diffuse large B cell, 1 Malt lymphoma, 1 Burkitt lymphoma, 2 Hodgkin-like PTLD. The response rate to rapamycin alone was 30.8%. The mean overall survival period was 23.38 months and 11 patients are still alive. In total, 10 patients (76.9%) achieved a complete remission with functioning graft in 11 (84.6%) patients. Conclusion: Despite the retrospective focus and limited number of patients, this study provides promising results regarding the effectiveness of stopping calcineurin inhibitors and switching to rapamycin for patients with PTLD.
کلیدواژه‌های انگلیسی مقاله Lymphoma Therapy,Rapamycin,Transplant
نویسندگان مقاله فرزانه اشرفی | farzaneh ashrafi
hematology division of internal medicine department, isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

شهرزاد شهیدی | shahrzad shahidi
nephrology division of internal medicine department, isfahan university of medical sciences, isfahan, iran ; kidney disease research center, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

زینب ابراهیمی | zeinab ebrahimi
isfahan university of medical sciences, isfahan, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مژگان مرتضوی | mojgan mortazavi
isfahan kidney disease research center, isfahan, iran.
نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/397
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