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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۸، شماره ۳، صفحات ۱۲-۱۹
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عنوان انگلیسی Evaluation of antagonistic effects of metformin with Cisplatin in gastric cancer cells.
چکیده انگلیسی مقاله Metformin has recently been introduced as an anti-cancer agent. In this study, we evaluated the effect of metformin and metformin/cisplatin on human gastric MKN-45 cell line. When we used metformin alone, it could inhibit proliferation and induce apoptosis, but it diminish anti-proliferative effects of cisplatin when they are used in combination. Further, we checked mRNA levels of survivin, mTOR, and Akt by real-time PCR. When MKN-45 cells were treated with metformin/cisplatin, the expression of survivin and mTOR were increased. The antagonistic effect of metformin on cisplatin could be through survivin and mTOR signaling pathways. Our results also suggest that interfering effect of metformin on cisplatin may be also through upregulation of Akt. Regarding the pivotal role of Akt in drug resistance, it may be reasonable to conclude that the antagonistic effect of metformin on cisplatin effect may be through this central mediator of drug resistance. Taken together, it seems that metformin is not a good option for sensitizing MKN-45 cell line to cisplatin, and in co-prescription of metformin and cisplatin in gastric cancer patients who suffer diabetes type 2, it should be highly cared.
کلیدواژه‌های انگلیسی مقاله Akt,Cisplatin,Gastric cancer,Metformin,Survivin,mTOR
نویسندگان مقاله وحید لسان | vahid lesan
hematology, oncology and stem cell transplantation research center, shariati hospital, tehran university of medical sciences, tehran, iran ; department of biology, faculty of food industry and agriculture, standard research institute sri , karaj, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید h غفاری | seyed h ghaffari
hematology, oncology and stem cell transplantation research center, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

جمیله سالار آملی | jamile salaramoli
department of basic science, faculty of veterinary medicine, university of tehran, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

منصور حیدری | mansour heidari
stem cell preparation unit, eye research center, farabi hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

معصومه رستمی | masoumeh rostami
hematology, oncology and stem cell transplantation research center, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کامران علی مقدم | kamran alimoghaddam
hematology, oncology and stem cell transplantation research center, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اردشیر قوام زاده | ardeshir ghavamzadeh
hematology, oncology and stem cell transplantation research center, shariati hospital, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/418
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