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Medical Journal of Islamic Republic of Iran، جلد ۲۸، شماره ۱، صفحات ۳۰۹-۳۱۴
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عنوان انگلیسی Evaluation of procalcitonin as a biomarker of diagnosis, severity and postoperative complications in adult patients with acute appendicitis
چکیده انگلیسی مقاله Background :Delay in diagnosis and treatment of acute appendicitis (AA) results in an increased rate of perforation, postoperative morbidity, mortality and hospital length of stay. Several biochemical parameters including white blood cell (WBC) count, C-reactive protein (CRP), interleukin-6 (IL6) and Procalcitonin (PCT) have been used to further improve the clinical diagnosis of AA. The aim of this study was to assess the value of procalcitonin as a predictor of diagnosis and severity of appendicitis in order to improve the clinical decision making, since other studies have been unable to demonstrate a diagnostic value for PCT elevation in acute appendicitis. Methods: One-hundred patients who underwent open appendectomy, including 75 men and 25 women with a mean age of 28 years were included in this study. Procalcitonin values were measured by an immunofluorescent method). Serum PCT>0.5 ng/ml was considered positive. The PCT serum values were measured in four different categories, including ˂0.5ng/ml, 0.5-2 ng/ml, 2-10ng/ml and more than 10ng/ml. Results: The sensitivity and specificity of PCT level measurement for acute appendicitis diagnosis were 44% and 100% respectively. The value of PCT increased with the severity of appendicitis and also with the presence of peritonitis and infection, at the site of surgery. Conclusions: Procalcitonin measurement cannot be used as a diagnostic test for adult patients with acute appendicitis and its routine use in such patients is not cost effective and conclusive. Procalcitonin values can be used as a prognostic marker and predictor of infectious complications following surgery and it can help to carry out timely surgical intervention which is highly recommended in patients with PCT values more than 0.5ng/ml.
کلیدواژه‌های انگلیسی مقاله Appendicitis, Procalcitonin, Diagnosis, Prognosis.
نویسندگان مقاله محمد وزیری | mohammad vaziri
minimally invasive surgery research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
سازمان های دیگر: Minimally Invasive Surgery Research center

فهیمه احسانی پور | fahimeh ehsanipour
department of pediatrics, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

عبدالرضا پازوکی | abdolreza pazouki
minimally invasive surgery research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
سازمان های دیگر: Minimally Invasive Surgery Research center

زینب تمنایی | zeinab tamannaie
minimally invasive surgery research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
سازمان های دیگر: Minimally Invasive Surgery Research center

تمنایی روح اله تقوی | tamannaie roohollah taghavi
minimally invasive surgery research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
سازمان های دیگر: Minimally Invasive Surgery Research center

محدثه پیشگاه رودسری | mohaddese pishgahroudsari
minimally invasive surgery research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
سازمان های دیگر: Minimally Invasive Surgery Research center

فاطمه جسمی | fatemeh jesmi
minimally invasive surgery research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
سازمان های دیگر: Minimally Invasive Surgery Research center

شهلا چایچیان | shahla chaichian
director of minimally invasive techniques research center, islamic azad university, tehran medical unit, endometriosis research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
سازمان های دیگر: Director of Minimally Invasive Techniques Research Center

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-680&slc_lang=en&sid=en
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