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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۷، شماره ۴، صفحات ۲۹-۳۳
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عنوان انگلیسی Kaposi's Sarcoma after Kidney Transplantation: a 21-Years Experience.
چکیده انگلیسی مقاله Introduction: The long-term use of immunosuppressive agents for prevention of allograft rejection increases the risk of malignancy approximately 100 times as high as that in the general population and Kaposi’s sarcoma (KS) is a relatively common malignancy after kidney transplantation. The aim of present study was to investigate the frequency of KS in patients with kidney transplantation in 20 years period. Material and methods: In this study Charts and pathology reports of 1487 recipients for kidney allografts treated at Imam Reza hospital between 1991 and 2012 were reviewed. The SPSS software package version 16 (SPSS Inc., Chicago, Illinois, USA) was used for the statistical analysis. Results: There were 17 of 1487 incident cases of KS kidney transplant population at our hospital in period of study. There is no significant difference between age and gender of patients. The mean time between transplantation and non-KS malignant tumors was 34.4 ± 21.8 months (range 12–140 months), while in KS patients it was 18.7 ± 25.2 months, which was statistically significantly different (P < 0.05). After detection of KS in 12 patients, we perform serum antibody detection against HHV. Among them, 8 (66.6%) were seropositive. Conclusion: KS is a common long-term complication in renal transplant recipients, with an increased incidence compared with the general population. Given that candidates for organ transplantation who are seropositive for HHV-8 -and thus at risk for KS- can now be identified, chemoprevention should be available in this high-risk population.
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نویسندگان مقاله داریوش رییسی | dariyush raeisi
department of nephrology, kermanshah university of medical science, kermanshah, iran.


مهرداد پاینده | mehrdad payandeh
medical biology research center, kermanshah university of medical sciences, kermanshah, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

سید حمید مدنی | seyed hamid madani
department of pathology, kermanshah university of medical science, kermanshah, iran.


محمد عرفان زارع | mohammad erfan zare
medical biology research center, kermanshah university of medical sciences, kermanshah, iran ; student research committee, kermanshah university of medical sciences, kermanshah, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

عاطفه نصیر کنسستانی | atefeh nasir kansestani
medical biology research center, kermanshah university of medical sciences, kermanshah, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

امیر حسین هاشمیان | amir hossein hashemian
research center for environmental determinants of health rcedh , kermanshah university of medical sciences, kermanshah, iran ; department of biostatistics and epidemiology, kermanshah university of medical sciences, school of public health, kermanshah, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/439
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