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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۷، شماره ۳، صفحات ۱۵-۲۰
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عنوان انگلیسی Immunohistochemical Analysis of p53, Ki-67, CD44, HER-2/neu Expression Patterns in Gastric Cancer, and Their Association with One Year Survival in North-West of Iran.
چکیده انگلیسی مقاله Introduction: Gastric cancer remains the second most common cause of cancer-related deaths worldwide. In many malignancies like, lung and breast, multiple prognostic factors are known, such as mutations in Ki-67, HER-2/neu, p53. In this study, we evaluated immunohistochemical protein expression patterns of cell-cycle-regulators p53, proliferation marker Ki-67, surface expression of CD44, HER-2/neu oncogene proposed as useful prognostic factors. Methods: In this descriptive-analytic study, we evaluate 100 patients with gastric cancer who were referred to Shahid Ghazi Hospital or other oncology clinics of Tabriz University of Medical Sciences in 2005-2010. Patients with pathologic confirmation of gastric cancer were selected. Expression of p53, ki-67, CD-44, HER-2/neu were detected by immunohistochemical staining. Results: In this study, 100 patients with gastric cancer participated. 76(76%) were men and 24(24%) were women with mean age of 64.02(8.05) years. Seventy two samples were intestinal type and 28 were diffuse type. CD44 was positive in 27(27%) patients. P53 was positive in 35(35%) patients. Ki-67 was positive in 53(53%) patients. HER-2/neu was positive in 51(51%) patients. Conclusion: The frequency of positive p53, Ki-67, CD44 and HER-2/neu varied in different studies. Positive Ki-67 and HER-2/neu were not associated with changes in survival but positive p53 and CD44 were significantly associated with improved survival.
کلیدواژه‌های انگلیسی مقاله CD-44,Gastric cancer,HER-2/neu,Ki-67,P53
نویسندگان مقاله زهره صناعت | zohreh sanaat
tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

منیره حلیمی | monireh halimi
tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

مرتضی ghojezadeh | morteza ghojezadeh
tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

امیر حسین pirovi | amir hossein pirovi
tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

جلیل واعظ قراملکی | jalil vaez gharamaleki
tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

علی اصفهانی جمال عیوضی ضیایی | ali esfahani jamal eivazi ziae
tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

ایرج اسودی کرمانی | iraj aswadi kermani
tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/449
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