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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۷، شماره ۱، صفحات ۱-۴
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عنوان انگلیسی Cyclooxygenase-2 expression in lymphoma in north-west of iran.
چکیده انگلیسی مقاله Background: Lymphomas are a group of malignancies affecting B, T and NK cells. COX-2 enzyme is one of the known inflammatory factors which increase in the inflammation process. Increase in COX-2 expression inhibits apoptosis and increases tumor cells invasion and angiogenesis. Increase in the COX-2 gene expression is seen in a group of cancers .Specific COX-2 inhibition also can be beneficial in some cancers through apoptosis stimulation. Materials & Methods: In a descriptive-analytic study, COX-2 expression degree was evaluated in patients with non-Hodgkin lymphoma. Patients’ cases were used to study the following variables: gender, age, lymphoma type, and stage of the disease, the degree of the disease, existence of B symptom, extranodal involvement, and response to treatment, death, and LDH levels. Paraffin-embedded tissue blocks from 153 cases of non-Hodgkin and Hodgkin lymphoma were selected for immunohistochemical staining for COX-2 expression. Results: COX-2 level were reported positive in four (4.7%),patients with non-Hodgkin lymphoma and four (5.7%), patients with Hodgkin lymphoma. During the seven year follow-up, 15 patients were suffering from the disease relapse and 9 patients died during this period. There were no significant relation between others quantitative and qualitative variables and COX-2 expression .Also, There was no relation between COX-2 and type of lymphoma (P=0.476). Conclusion: According to our results, there was no relation between cox-2 expression and type of lymphoma. We recommend more patients are needed for more assess cox-2 expression. On the other hand, in our study most of the patients had Azari Race, may be, have an effect in our results.
کلیدواژه‌های انگلیسی مقاله COX-2,Hodgkin lymphoma,Non-Hodgkin lymphoma
نویسندگان مقاله زهره صناعت | zohreh sanaat
associate professor of hematology-oncology, hematology-oncology research center, tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

سید محمد توانگر | seyed mohammad tavangar
professor of pathology, pathology department, shariati hospital, tehran university of medical science, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

جلیل واعظ قراملکی | jalil vaez gharamaleki
professor of hematology-oncology, hematology-oncology research center, tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

ایرج اسودی کرمانی | iraj aswadi kermani
professor of hematology-oncology, hematology-oncology research center, tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

جمال عیوضی ضیایی | jamal eivazi ziae
associate professor of hematology-oncology, hematology-oncology research center, tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

علیرضا نیکانفر | alireza nikanfar
associate professor of hematology-oncology, hematology-oncology research center, tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

علی اصفهانی | ali esfahani
assistant professor of hematology-oncology, hematology-oncology research center, tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

سید هادی چاوشی | seyyed hadi chavoshi
assistant professor of hematology-oncology, hematology-oncology research center, tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

h بیورانی | h bevrani
assistant professor of statistic, faculty of mathematic, tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

فریده اکبری | farideh akbari
internist, hematology-oncology research center, tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/467
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