این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Hematology-Oncology and Stem Cell Research، جلد ۶، شماره ۲، صفحات ۸-۱۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Chemotherapy Toxicity in Acute Lymphoblastic and Myelogenous Leukemia
چکیده انگلیسی مقاله Background and Aims : Adverse drug reactions (ADRs) are one of the major leading causes of death in the world. This study was designed and conducted because of the importance of adverse events in the cancer treatment setting and regarding this issue there is no study exploring adverse reactions of acute hematologic malignancy chemotherapy in Iranian population. Methods : This was a prospective, cross-sectional study performed at hematology-oncology and bone marrow transplantation research center. The inclusion criteria were all patients with acute hematologic malignancies such as ALL and AML , which were admitted over an 8 months period and were ≥15 years old age. Each ADR was categorized based on the WHO system organ classification. Results and Conclusion : The total number of detected ADRs was 310 in total of 105 patients. Eight patients (7.6 %) experienced only one ADR, eleven patients (10.5%) experienced two ADRs and eighty-six of them (82%) experienced more than two ADRs. there was a significant relationship between the number of ADRs and type of hematologic malignancy. In this regard, the patients with AML malignancy showed more number of ADRs than with ALL malignancy ( p < 0.05) The Gastro-intestinal system disorders were the most common affected system-organ by chemotherapy regimens (33.5%). We suggest more well designed studies to determine the relation between the number of ADRs and study factors.
کلیدواژه‌های انگلیسی مقاله ALL,AML,Chemotherapy,Adverse drug reactions,Toxicity
نویسندگان مقاله طاهر انتظاری ملکی | taher entezari maleki
department of clinical pharmacy, faculty of pharmacy, tabriz university of medical sciences, tabriz,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

صفا مرگدری | safa margedari
department of clinical pharmacy, faculty of pharmacy, tehran university of medical sciences, tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

خیراله غلامی | kheirollah gholami
faculty of pharmacy, and research center for rational use of drug, tehran university of medical sciences, tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ملوک حاجی بابایی | molouk hadjibabaie
faculty of pharmacy, and research center for rational use of drug, tehran university of medical sciences, tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد باقر اوغازیان | mohammad bagher oghazian
department of clinical pharmacy, faculty of pharmacy, tehran university of medical sciences, tehran,

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

جمشید سلام زاده | jamshid salamzadeh
department of clinical pharmacy, faculty of pharmacy, shahid beheshti university of medical sciences, tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

سید حمید خویی | seyed hamid khoee
department of clinical pharmacy, faculty of pharmacy, tehran university of medical sciences, tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اردشیر قوام زاده | ardeshir ghavamzadeh
hematology-oncology and sct research center, department of hematology-oncology, shariati hospital, tehran university of medical sciences, tehran,iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/328
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Articles
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات