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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۵، شماره ۱، صفحات ۱۱-۱۵
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عنوان انگلیسی Autologous and Allogeneic Hematopoetic Stem Cell Transplantation for Solid Tumors in Iran
چکیده انگلیسی مقاله Introductio: Hematopoietic stem cell transplants (HSCT) are considered as treatment options for patients with solid tumors. Transplant numbers have changed significantly over the last decade. We have done Autologous and Allogeneic HSCT for treatment of solid tumor patients in our center. Methods: In order to show the transplant effect on solid tumor treatment, we collected data from 71 patients (7 allogeneic, and 64 autologous) who had undergone HSCT from 1991 to 2011 in our center. The median age of patients was 19.5 years (range: 2-58). The Male/Female ratio was 41/30. The most common transplant diseases were Neuroblastoma (18, 25.7%), Germ Cell Tumors (13, 18.6%) and Breast Cancer (11, 15.7%). 67 patients (95.7%) received peripheral blood and the 3 other ones (4.3%) received bone marrow as a source of SCT. Results: The median time of hospitalization after high-dose therapy was 24 days (range: 11-50 days; 23 days for autologous and 29 days for allogeneic patients). At present, 57 patients (80%) are still alive with median follow-up of 9 months. Transplant-related mortality (TRM) was 4.3%. The causes of death were progressive disease, metastasis and multi-organ failure. 2-year overall and disease-free survivals were 81.7% and 72%, respectively (for the autologous patients overall and disease-free survivals were 80.7% and 71.1%, respectively). Among 7 patients with allogeneic transplantation, 2 developed acute-graft-versus host disease (GVHD) and 4 developed chronic GVHD. One patient had chronic GVHD following acute GVHD. Conclusion: Our study reveals promising results of HSCT in the treatment of some solid tumors. In other hand, more additional trial study is needed.
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نویسندگان مقاله اردشیر قوام زاده | ardeshir ghavamzadeh
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

روشنک درخشنده | roshanak derakhshandeh
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

آرش جلالی | arash jalali
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی جعفرپور | ali jafarpour
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کامران علی مقدم | kamran alimoghaddam
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

امیرعلی حمیدیه | amirali hamidieh
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بابک بهار | babak bahar
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مسعود ایروانی | masoud iravani
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید اسدالله موسوی | seied asadollah mousavi
hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد جهانی | mohammad jahani


نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/266
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