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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۴، شماره ۴، صفحات ۱۴-۱۶
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عنوان انگلیسی Interaction between HER-2 and Hormone Receptors in Breast Cancer
چکیده انگلیسی مقاله Introduction: Breast cancer is the most common malignancy with more than one million new cases diagnosed annually all around the world. Its growth is mostly regulated by steroid hormones such as estrogen and peptide growth factors in interaction with epidermal growth factor 1 and 2. Methods and materials: In this study, 237 patients who had consulted the Oncology Clinic of Tabriz University of Medical Sciences with pathologic diagnosis of breast cancer (from 2003 to 2010) were involved. Data was extracted from medical records. Results: From the total of 237 patients, 50.6% were ER + , 48.9% were PR + and 37.1% were HER-2 + . The greatest percentage of HER-2positivity (51.6%) was detected in the age group of patients over 60 and the least in the group aged 31 to 40 yrs. The greatest percentage of HR + (71%) patients were also over 60 and the least (50%) were less than 30. 35.5% of patients in pre- menstrual period were HER-2 + . HR was positive in 64% of LN + patients; HER- 2 and HRwere positive in 35.4% and 65.4% while in LN - patients they were positive in 39% and 61.9% of cases, respectively. Conclusion: Acquired data showed reverse relation between the expression of epidermal growth factor II and hormone receptors in breast cancer. 40-55% of cases with epidermal growth factor expression lacked hormone receptors. Co-existence of hormone receptors and HER-2 expression in breast cancer are considered as important prognostic factors.
کلیدواژه‌های انگلیسی مقاله Breast Cancer,HER-2,Hormone Receptors
نویسندگان مقاله مجید مقدس زاده | majid moghadaszadeh
tabriz islamic azad university, tabriz, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

علیرضا نیکانفر | alireza nikanfar
hematology and oncology department, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

محمدرضا همتی | mohamadreza hemati
tabriz islamic azad university, tabriz, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

بهروز غریب | behrouz gharib
hematology- oncology and stem cell research center, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سارا سردشتی | sara sardashti
hematology and oncology department, tabriz university of medical sciences, tabriz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/258
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