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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۴، شماره ۳، صفحات ۱۰-۱۳
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عنوان انگلیسی Drug Utilization Review of Vancomycin in Febrile Neutropenic Patients Hospitalized at a Bone Marrow Transplantation Center
چکیده انگلیسی مقاله Introduction : Infections in neutropenic patients are considered as major causes of mortality and emergence of drug resistant Gram positive bacterial infections are crucially important to be covered if indicated. Vancomycin is active against most Gram positive bacteria including methicillin resistant Staphylococcus aureus (MRSA). In this study, we evaluated the appropriate utilization of this agent. Methods : We conducted a prospective observational study at bone marrow transplantation research center, Shariati teaching hospital in Tehran to evaluate the appropriateness of vancomycin utilization for our adult bone marrow transplantation (BMT) patients for a period of six months. Results : The charts of a total of 117 patients were prospectively reviewed in 3 adult BMT wards. Seventy four patients (63.2%) received vancomycin treatment during their hospital stay. Most patients received allogienic versus autologous transplantation (62.2%, 18.9%). Majority of patients were under 50 years of age (91.9%). About 58% of cases were febrile neutropenic at the time of vancomycin initiation. Based on the criteria of appropriate indications, vancomycin utilization was justified in 59.5% of cases which 43.2% of those cases received appropriate initial doses. Conclusion : Based on the results of this study, in the majority of our BMT patients vancomycin was utilized appropriately as a part of their empiric treatment. More attention in the time of initiation and also dose adjustment seems to be necessary to minimize treatment failure and the emergence of drug resistance.
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نویسندگان مقاله علیرضا hayatshahi | alireza hayatshahi
pharmd, bcps, clinical pharmacist, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا جوادی | mohammadreza javadi
pharmd, bcps, clinical pharmacist, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسن ترکمندی | hassan torkamandi
pharmd, pharmacist, pharmaceutical care department, dr.shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ملوک حاجی بابایی | molouk hadjibabaie
pharmd, bcps, clinical pharmacist, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سارا الهیاری | sara alahyari
pharmd, pharmacist, pharmaceutical care department, dr.shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

خیراله غلامی | kheirollah gholami
pharmd, bcps, clinical pharmacist, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کامران علی مقدم | kamran alimoghaddam
hematology– oncology department, hematology– oncology and stem cell research center, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مسعود ایروانی | masoud iravani
hematology– oncology department, hematology– oncology and stem cell research center, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اردشیر قوام زاده | ardeshir ghavamzadeh
hematology– oncology department, hematology– oncology and stem cell research center, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/250
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