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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۳، شماره ۳، صفحات ۱۷-۲۰
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عنوان انگلیسی High Prevalence of Hypoparathyroidism in Patients with beta-Thalassemia Major
چکیده انگلیسی مقاله Introduction: Hypoparathyroidism (HPT) is an irreversible but preventable disorder caused by an iron overload which can be considered a typical complication in patients with beta-thalassemia major. Patients and method: Parathyroid function was evaluated in 130 patients in Qom, Iran, who suffered from beta-thalassemia major. Their serum ferritin levels were checked for monitoring of chelation therapy effects. Results: The prevalence of HPT was 14.6% (19/130). The median age of patients with HPT was significantly higher than of patients without HPT (18 vs. 15 years; P=0.03). Serum ferritin levels was not significantly different between the two groups (median: 2709 vs. 1512; P=0.95). The prevalence of cardiac diastolic dysfunction in patients with HPT was significantly higher than in normal thalassemic patients (3.1% vs. 15.8%, P=0.04). Patients with hypoparathyroidism demonstrated abnormal glucose metabolism (0% vs. 15.8%; P=0.003). Conclusion: the high prevalence of hypoparathyroidism demonstrated poor chelation therapy in these patients. Close monitoring of ferritin level was recommended. Also, the measurement of parathyroid hormone on a regular basis for all thalassemic patients was recommended.
کلیدواژه‌های انگلیسی مقاله beta-Thalassemia major,Hypoparathyroidism,Ferritins
نویسندگان مقاله امیر علی حمیدیه | amir ali hamidieh
pediatric hematology- oncology and stem cell transplantation department, hematology- oncology and stem cell transplantation research center, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

b moradbeag | b moradbeag
faculty of medicine, qom islamic azad university, qom, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

f پاشا | f pasha
faculty of medicine, tehran islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهدی جلیلی | mehdi jalili
pediatric hematology- oncology and stem cell transplantation department, ematology- oncology and stem cell transplantation research center, shariati hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m حاجی بابایی | m hadjibabaie
clinical pharmacology department, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

m کشاورزنیا | m keshavarznia
faculty of medicine, qom islamic azad university, qom, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/219
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